Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
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TLDR
The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.Abstract:
In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.read more
Citations
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Journal ArticleDOI
Isolation and characterization of rat pituitary endothelial cells.
Kirti Chaturvedi,Dipak K. Sarkar +1 more
TL;DR: The results suggest that a magnetic separation technique can be used for enrichment of pituitary-derived endothelial cells for determination of cellular mechanisms governing the vascularization in the pituitsary.
Journal ArticleDOI
Cancer as a programmed death of an organism.
TL;DR: The hypothesis introduces the idea that there is a critical level of mutagenesis that triggers a program of organism death by means of proliferation of killer cells.
Journal ArticleDOI
MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer.
TL;DR: It is demonstrated that microRNA-760 exhibited a suppressive role in gastric cancer via inhibiting BST2, indicating that miR-760/BST2 axis may provide promising therapeutic target for gastriccancer.
Book ChapterDOI
The Tumor Microenvironment: Focus on Extracellular Matrix.
Nathia Nathaly Rigoglio,Ana Carolina Silveira Rabelo,Jéssica Borghesi,Gustavo de Sá Schiavo Matias,Paula Fratini,Pedro H.D.M. Prazeres,Concepta Margaret McManus Pimentel,Alexander Birbrair,Alexander Birbrair,Maria Angélica Miglino +9 more
TL;DR: ECM components have an increasingly important role in carcinogenesis and this leads us to believe that their understanding may be a key in the discovery of new anti-tumor therapies.
Journal ArticleDOI
Effects of recombinant human canstatin protein in the treatment of pancreatic cancer.
Xiao-Ping He,Zhao-Shen Li,Ren-Min Zhu,Zhen-Xing Tu,Jun Gao,Xue Pan,Yan-Fang Gong,Jing Jin,Xiaohua Man,Hongyu Wu,Ai-Fang Xu +10 more
TL;DR: Findings demonstrate that the rhCanstatin effectively retards the growth of pancreatic cancer in a dose-dependent manner through inhibiting angiogenesis and may be a promising therapeutic agent for pancreatic cancers treatment in the clinic.
References
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Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Integrins: versatility, modulation, and signaling in cell adhesion.
Journal ArticleDOI
Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
Journal ArticleDOI
Angiogenesis in cancer and other diseases
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Pathological angiogenesis is a hallmark of cancer and various ischaemic and inflammatory diseases and integrated understanding is leading to the development of a number of exciting and bold approaches to treat cancer and other diseases, but owing to several unanswered questions, caution is needed.
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