Journal ArticleDOI
Basement membranes: structure, assembly and role in tumour angiogenesis
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TLDR
The basement membrane (BM) as mentioned in this paper is a specialized form of extracellular matrix (ECM) which mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment.Abstract:
In recent years, the basement membrane (BM)--a specialized form of extracellular matrix (ECM)--has been recognized as an important regulator of cell behaviour, rather than just a structural feature of tissues. The BM mediates tissue compartmentalization and sends signals to epithelial cells about the external microenvironment. The BM is also an important structural and functional component of blood vessels, constituting an extracellular microenvironment sensor for endothelial cells and pericytes. Vascular BM components have recently been found to be involved in the regulation of tumour angiogenesis, making them attractive candidate targets for potential cancer therapies.read more
Citations
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Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Journal ArticleDOI
Matrix metalloproteinases and the regulation of tissue remodelling
TL;DR: Recent studies in mice and flies point to essential roles of MMPs as mediators of change and physical adaptation in tissues, whether developmentally regulated, environmentally induced or disease associated.
Journal ArticleDOI
The biology and function of fibroblasts in cancer
TL;DR: Cancer-associated fibroblasts (CAFs) become synthetic machines that produce many different tumour components and have a role in creating extracellular matrix structure and metabolic and immune reprogramming of the tumour microenvironment with an impact on adaptive resistance to chemotherapy.
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Stromal fibroblasts in cancer initiation and progression
TL;DR: It is revealed that fibroblasts have a more profound influence on the development and progression of carcinomas than was previously appreciated and this has important therapeutic implications.
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Influence of tumour micro-environment heterogeneity on therapeutic response
TL;DR: The dynamic tumour topography varies drastically even throughout the same lesion, so evaluating tumours as complete organs, and not simply as masses of transformed epithelial cells, becomes paramount.
References
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Journal ArticleDOI
How Matrix Metalloproteinases Regulate Cell Behavior
Mark D. Sternlicht,Zena Werb +1 more
TL;DR: Recent advances shed light on how the structure and function of the MMPs are related and on how their transcription, secretion, activation, inhibition, localization, and clearance are controlled.
Journal ArticleDOI
Vascular endothelial growth factor (VEGF) and its receptors
TL;DR: Recent developments that have widened considerably the understanding of the mechanisms that control V EGF production and VEGF signal transduction are focused on and recent studies that have shed light on the mechanisms by which VEGf regulates angiogenesis are reviewed.
Journal ArticleDOI
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
TL;DR: The studies that brought MPIs into clinical testing are reviewed and the design and outcome of the trials are discussed in light of new information about the cellular source, substrates, and mode of action of MMPs at different stages of tumor progression.
Journal ArticleDOI
Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Gabriele Bergers,Rolf A. Brekken,Gerald McMahon,Thiennu H. Vu,Takeshi Itoh,Kazuhiko Tamaki,Kazuhiko Tanzawa,Philip E. Thorpe,Shigeyoshi Itohara,Zena Werb,Douglas Hanahan +10 more
TL;DR: The results show that MMP-9 is a component of theAngiogenic switch, and MMP inhibitors reduce angiogenic switching, and tumour number and growth, as does genetic ablation of M MP-9.
Journal ArticleDOI
Transplacental carcinogenesis by stilbestrol
TL;DR: It is argued the cause-and-effect relationship between in utero exposure to diethylstilbestrol and incidence of vaginal adenocarcinoma among young women and a ban of such diet supplementation of human foodstuffs is called for.
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