Open Access
Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE
Marc Humbert,Richard Beasley,J. Ayres +2 more
- pp 425-434
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The article was published on 2017-01-01 and is currently open access. It has received 848 citations till now. The article focuses on the topics: Omalizumab.read more
Citations
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Journal ArticleDOI
The path to personalized medicine in asthma.
Diego Bagnasco,Matteo Ferrando,Stefano Bernardi,Giovanni Passalacqua,Giorgio Walter Canonica +4 more
TL;DR: Asthma therapy is changing from a ’one size fits all’ therapy to a ‘precision medicine’ model, where the most appropriate treatment for each patient is prescribed, and the possibility to act a “sequential bio-combination therapy’ can be envisaged, using different biological drugs in the same patient to act on different pathophysiological mechanisms.
Journal ArticleDOI
Novel monoclonal treatments in severe asthma
TL;DR: Research on the biological treatment of asthma shows promising results, and anti-IgE (omalizumab) has recently been approved for use, whereas those targeting TSLP, IL-9, and TNF-α lacked convincing effectiveness.
Journal ArticleDOI
Novel targets of omalizumab in asthma.
TL;DR: Omalizumab may have an antiviral effect when used as a preventive therapy for fall exacerbations in children and teenagers and may have corticosteroid-sparing effect in a subset of patients with eosinophilic granulomatosis with polyangiitis.
Journal ArticleDOI
Anti-IgE monoclonal antibody for treatment of asthma and other manifestations related to allergic diseases
TL;DR: The paper emphasizes the central role IgE plays in allergic diseases and the biological rationale for its use, the evidence upon which the current recommendations for the use of anti-IgE in uncontrolled asthma are based and its possible future applications.
References
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Journal ArticleDOI
Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials.
Elizabeth F. Juniper,Gordon H. Guyatt,Robert S. Epstein,Penelope J. Ferrie,Roman Jaeschke,T K Hiller +5 more
TL;DR: A questionnaire suitable for all adults with asthma and designed to be responsive to within subject change and therefore may be used as a measure of outcome in clinical trials in asthma is developed.
Allergy, rhinitis, other respiratory diseases Omalizumab, anti-IgE recombinant humanized monoclonal antibody, for the treatment of severe allergic asthma
William W. Busse,Jonathan Corren,Bobby Q. Lanier,Margaret McAlary,Angel FowlerTaylor,Giovanni Della Cioppa,Niroo Gupta,Fort Worth +7 more
TL;DR: Omalizumab as discussed by the authors is a recombinant humanized anti-IgE mAb, which forms complexes with free IgE, blocking its interaction with mast cells and basophils.
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Proceedings of the ATS Workshop on Refractory Asthma Current Understanding, Recommendations, and Unanswered Questions
Sally E. Wenzel,John V. Fahy,Charles G. Irvin,Stephen P. Peters,Sheldon L. Spector,Stanley J. Szefler,Thomas B. Casale,Michelle M. Cloutier,Jack A. Elias,Mark C. Liu,Virginia Taggert +10 more
TL;DR: The proceedings of an American Thoracic Society (ATS)-sponsored workshop are hoped to serve as an aid to begin to define, understand, and manage these refractory patients.
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The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics
Markus Solèr,J. Matz,Robert G. Townley,R. Buhl,J. O'Brien,Howard Fox,J. Thirlwell,N. Gupta,G. Della Cioppa +8 more
TL;DR: Results indicate that omalizumab therapy safely improves asthma control in allergic asthmatics who remain symptomatic despite regular use of inhaled corticosteroids and simultaneous reduction in Corticosteroid requirement.