Beyond neurons: Involvement of urothelial and glial cells in bladder function
Lori A. Birder,Amanda Wolf-Johnston,Manjul Kiran Chib,C. A. Buffington,James R. Roppolo,Ann T. Hanna-Mitchell +5 more
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TLDR
This work investigated whether changes in physiologic parameters occur within 3 cell types associated with sensory transduction in the urinary bladder: 1) the urothelium, 2) identified bladder dorsal root ganglion (DRG) neurons and 3) grey matter astrocytes in the lumbosacral (S1) spinal cord.Abstract:
Aim
The urothelium, or epithelial lining of the lower urinary tract (LUT), is likely to play an important role in bladder function by actively communicating with bladder nerves, smooth muscle, and cells of the immune and inflammatory systems. Recent evidence supports the importance of non-neuronal cells that may extend to both the peripheral and central processes of the neurons that transmit normal and nociceptive signals from the urinary bladder. Using cats diagnosed with a naturally occurring syndrome termed feline interstitial cystitis (FIC), we investigated whether changes in physiologic parameters occur within 3 cell types associated with sensory transduction in the urinary bladder: 1) the urothelium, 2) identified bladder dorsal root ganglion (DRG) neurons and 3) grey matter astrocytes in the lumbosacral (S1) spinal cord. As estrogen fluctuations may modulate the severity of many chronic pelvic pain syndromes, we also examined whether 17β-estradiol (E2) alters cell signaling in rat urothelial cells.read more
Citations
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Nerve growth factor in bladder dysfunction: contributing factor, biomarker, and therapeutic target.
TL;DR: Using novel experimental tools, such as urothelium‐specific NGF transgenic mice or more specific low‐molecular weight NGF receptor modulators, may provide better understanding of several unresolved issues in NGF‐related bladder dysfunction.
Journal ArticleDOI
Idiopathic cystitis in domestic cats--beyond the lower urinary tract.
TL;DR: Research investigations into the various abnormalities present in cats are summarized to compare some of these findings with those identified in human beings, and to discuss how they might modify perceptions about the etiopathogenesis, diagnosis, and treatment of cats with this disease.
Journal ArticleDOI
The role of the transient receptor potential (TRP) superfamily of cation-selective channels in the management of the overactive bladder
TL;DR: The role of the transient receptor potential (TRP) channel superfamily in normal human bladder function is still controversial as discussed by the authors, and the role of this channel in the pathophysiology and treatment of particularly neurogenic DO is well established.
Journal ArticleDOI
Models of Inflammation of the Lower Urinary Tract
TL;DR: Comparative and translational studies are required if the full potential of findings obtained with animal models to improve prevention and treatment of lower urinary tract inflammation in people is to be realized.
Journal ArticleDOI
Evidence for Bladder Urothelial Pathophysiology in Functional Bladder Disorders
TL;DR: A review of bladder conditions typified by lower urinary tract symptoms including urinary frequency, urgency, urgency incontinence, nocturia, and bladder discomfort or pain suggests BPS/IC, FIC, and OAB appear to share some common pathophysiology including increased purinergic, TRPV1, and muscarinic signaling, increased urothelial permeability, and aberrant u rothelial differentiation.
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The Fine Structure of the Nervous System: Neurons and Their Supporting Cells
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