Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular System
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TLDR
The biochemistry of Nox enzymes expressed in the cardiovascular system (Nox1, 2, 4, and 5), their roles in cardiovascular cell biology, and their contributions to disease development are discussed.Abstract:
atherosclerosis, hypertension, cardiac hypertrophy and remodeling, angiogenesis and collateral formation, stroke, and heart failure. In this review, we discuss in detail the biochemistry of Nox enzymes expressed in the cardiovascular system (Nox1, 2, 4, and 5), their roles in cardiovascular cell biology, and their contributions to disease development.read more
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References
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Journal ArticleDOI
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Karen Bedard,Karl-Heinz Krause +1 more
TL;DR: This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.
Journal ArticleDOI
Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
Ulf Landmesser,Sergey Dikalov,S. Russ Price,Louise McCann,Tohru Fukai,Steven M. Holland,William E. Mitch,David G. Harrison +7 more
TL;DR: Evidence is obtained that hypertension produces a cascade involving production of ROSs from the NADPH oxidase leading to oxidation of tetrahydrobiopterin and uncoupling of endothelial NO synthase (eNOS), which decreases NO production and increases ROS production from eNOS.
Journal ArticleDOI
Role of the T cell in the genesis of angiotensin II–induced hypertension and vascular dysfunction
Tomasz J. Guzik,Nyssa E. Hoch,Kathryn A. Brown,Louise McCann,Ayaz Rahman,Sergey Dikalov,Jörg J. Goronzy,Cornelia M. Weyand,David G. Harrison +8 more
TL;DR: A previously undefined role for T cells in the genesis of hypertension is identified and a role of inflammation in the basis of this prevalent disease isSupporting a novel therapeutic target for the treatment of high blood pressure.
Journal ArticleDOI
Cell transformation by the superoxide-generating oxidase Mox1
Young Ah Suh,Rebecca S. Arnold,Bernard Lassègue,Jing Shi,Xiang Xi Xu,Dan Sorescu,Andrew B. Chung,Kathy K. Griendling,J. David Lambeth +8 more
TL;DR: The cloning of mox1 is described, which encodes a homologue of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox, which is expressed in colon, prostate, uterus and vascular smooth muscle, but not in peripheral blood leukocytes.
Journal ArticleDOI
Vascular NAD(P)H oxidases: specific features, expression, and regulation
Bernard Lassègue,Roza E. Clempus +1 more
TL;DR: Members of this enzyme family appear to be important in vascular biology and disease and constitute promising targets for future therapeutic interventions.
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