Journal ArticleDOI
Biological activity and pharmacological prospects of lupane terpenoids: I. natural lupane derivatives
TLDR
The biological activity of natural and semisynthetic lupane triterpenoids is discussed in a two-part review.Abstract:
The biological activity of natural and semisynthetic lupane triterpenoids is discussed in a two-part review. The first part is devoted to the pharmacological properties of natural lupane triterpenoids. Betulinic acid has proven to be the most effective antitumor agent among more than fifty natural lupanes.read more
Citations
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Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation.
Cristina Dehelean,Codruţa Şoica,Ionuţ Ledeţi,Mihaela Aluas,István Zupkó,Atena Gǎluşcan,Simona Cinta-Pinzaru,Melania Munteanu +7 more
TL;DR: The research revealed the efficacy of the extraction procedures as well as the antiproliferative and anti-inflammatory effects of birch extracts.
Journal ArticleDOI
Antiprotozoal activity of Betulinic acid derivatives
D.B. Domínguez-Carmona,Fabiola Escalante-Erosa,Karlina García-Sosa,G. Ruiz-Pinell,David Gutierrez-Yapu,Manuel Jesús Chan-Bacab,Alberto Giménez-Turba,Luis M. Peña-Rodríguez +7 more
TL;DR: The results showed that modifying the C-3 position increases leishmanicidal activity while modification of theC-3 and C-28 positions decreases trypanocidal activity.
Journal ArticleDOI
High value triterpenic compounds from the outer barks of several Eucalyptus species cultivated in Brazil and in Portugal
Rui M. A. Domingues,G.D.A. Sousa,Carlos M. Silva,Carmen S. R. Freire,Armando J. D. Silvestre,C. Pascoal Neto +5 more
TL;DR: The chemical composition of the lipophilic extracts of the inner and outer bark fractions of Eucalyptus grandis (E. grandis× Eucaliaptus urophylla) was studied by gas chromatography-mass spectrometry.
Journal ArticleDOI
Secondary metabolite profiling of Curcuma species grown at different locations using GC/TOF and UPLC/Q-TOF MS.
Jueun Lee,Youngae Jung,Jeoung-Hwa Shin,Ho Kyoung Kim,Byeong Cheol Moon,Do Hyun Ryu,Geum-Sook Hwang +6 more
TL;DR: A combination of GC- and LC-MS allowed us to analyze curcuminoids and terpenoids, the typical bioactive compounds of Curcuma, which can be used to discriminate CurCuma samples according to species or geographical origin.
Journal ArticleDOI
A practical synthesis of betulinic acid
TL;DR: In this article, a new synthetic route for the synthesis of betulinic acid from betulin has been developed, which is the main step of this procedure is the selective oxidation of the primary alcohol function of Betulin without affecting the secondary hydroxyl group.
References
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Journal ArticleDOI
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
E. Pisha,Heebyung Chai,Ik-Soo Lee,T E Chagwedera,Norman R. Farnsworth,Geoffrey A. Cordell,Chris Beecher,Harry H. S. Fong,A. D. Kinghorn,David M. Brown,David M. Brown +10 more
TL;DR: As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
Journal ArticleDOI
On the origins of triterpenoid skeletal diversity.
TL;DR: The triterpenoids are a large group of natural products derived from C(30) precursors and each of these structures is classified and mechanisms for their formation are provided.
Journal ArticleDOI
Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.
Toshihiro Fujioka,Yoshiki Kashiwada,Robert E. Kilkuskie,L. M. Cosentino,Lawrence M. Ballas,Jack B. Jiang,William P. Janzen,Ih-Sheng Chen,Kuo Hsiung Lee +8 more
TL;DR: Evaluation of anti-HIV activity with eight derivatives of 1 revealed that dihydrobetulinic acid was also a potent inhibitor of HIV replication, and there was no apparent correlation between anti-hIV activity and the inhibition of PKC among these compounds.
Journal ArticleDOI
The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.
Monika Raisova,Amir M. Hossini,Jiirgen Eberle,Christian Riebeling,Thomas Wieder,Isrid Sturm,Peter T. Daniel,Constantin E. Orfanos,Christoph C. Geilen +8 more
TL;DR: Bcl-2 overexpression abolished apoptosis triggered by both apoptotic stimuli, confirming the critical role of the Bax/B cl-2 ratio as a rheostat that determines the susceptibility to apoptosis in melanoma cells by regulating mitochondrial function.
Journal ArticleDOI
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
TL;DR: Because of its selective cytotoxicity against tumor cells and favorable therapeutic index, even at doses up to 500 mg/kg body weight, betulinic acid is a very promising new chemotherapeutic agent for the treatment of HIV infection and cancer.