Journal ArticleDOI
Pharmacological activities of natural triterpenoids and their therapeutic implications
Petr Dzubak,Marian Hajduch,David Vydra,Alica Hustova,Miroslav Kvasnica,David Biedermann,Lenka Marková,Milan Urban,Jan Sarek +8 more
TLDR
The pharmacological activity of naturally occurring triterpenoids excluding the degraded triter penoids and cucurbitacins is reviewed, which includes anticancer, anti-inflammatory, antiulcerogenic, antimicrobial and antiviral activity.About:
This article is published in Natural Product Reports.The article was published on 2006-06-01. It has received 602 citations till now. The article focuses on the topics: Cucurbitacins.read more
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Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
TL;DR: Synthetic oleanane triterpenoids and rexinoids are two new classes of multifunctional drugs that have unique molecular and cellular mechanisms of action and might prove to be synergistic with standard anti-cancer treatments.
Journal ArticleDOI
α-Amylase inhibitors: a review of raw material and isolated compounds from plant source.
Paloma Michelle de Sales,Paula Monteiro Souza,Luiz Alberto Simeoni,Pérola Oliveira Magalhães,Dâmaris Silveira +4 more
TL;DR: Amongst the phyto-constituents that have been investigated, flavonoids are one of them that demonstrated the highest inhibitory activities with the potential of inhibition related to number of hydroxyl groups in the molecule of the compound.
Journal ArticleDOI
Supercritical fluid extraction of vegetable matrices: Applications, trends and future perspectives of a convincing green technology
TL;DR: The most comprehensive picture over SFE of vegetable matrices is provided in this review, highlighting pertinent aspects and opportunities that may further consolidate the convincing route of this technology for the next years.
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Birch bark research and development
TL;DR: Current and future applications of birch bark natural products in pharmaceuticals, cosmetics, and dietary supplements for the prevention and treatment of cancer, HIV, and other human pathogens are reviewed.
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Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities
TL;DR: The current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented.
References
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Journal ArticleDOI
Pharmacology of oleanolic acid and ursolic acid
TL;DR: Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals and have been noted for their antitumor-promotion effects, which are stimulating additional research in this field.
Journal ArticleDOI
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis
E. Pisha,Heebyung Chai,Ik-Soo Lee,T E Chagwedera,Norman R. Farnsworth,Geoffrey A. Cordell,Chris Beecher,Harry H. S. Fong,A. D. Kinghorn,David M. Brown,David M. Brown +10 more
TL;DR: As a result of bioassay–guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma–specific cytotoxic agent and antitumour activity was mediated by the induction of apoptosis.
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Causes and consequences of tumour acidity and implications for treatment
TL;DR: Molecular genetic approaches have revealed hypoxia-induced coordinated upregulation of glycolysis, a potentially important mechanism for establishing the metabolic phenotype of tumours, and opening up new opportunities for therapy.
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Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
Albena T. Dinkova-Kostova,Karen T. Liby,Katherine K. Stephenson,W. David Holtzclaw,Xiangqun Gao,Nanjoo Suh,Charlotte R. Williams,Renee Risingsong,Tadashi Honda,Gordon W. Gribble,Michael B. Sporn,Paul Talalay +11 more
TL;DR: This work shows that synthetic triterpenoid analogues of oleanolic acid are extremely potent inducers of the phase 2 response [e.g., elevation of NAD(P)H-quinone oxidoreductase and heme oxygenase 1], which is a major protector of cells against oxidative and electrophile stress.
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Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
TL;DR: Because of its selective cytotoxicity against tumor cells and favorable therapeutic index, even at doses up to 500 mg/kg body weight, betulinic acid is a very promising new chemotherapeutic agent for the treatment of HIV infection and cancer.