Journal ArticleDOI
Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity.
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TLDR
An overview of the catalogue of AMPAR interacting proteins and how they contribute to the complex biology of this central glutamate receptor can be found in this article, where an array of transmembrane proteins operate as auxiliary subunits that in addition to receptor trafficking and stabilization also substantially impact AMPAR gating and pharmacology.About:
This article is published in Neuropharmacology.The article was published on 2021-07-13. It has received 11 citations till now. The article focuses on the topics: Ionotropic glutamate receptor & AMPA receptor.read more
Citations
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Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance
TL;DR: In this paper , a patch-clamp electrophysiological recording from heterologously expressed AMPARs was used to characterize the actions of the γ8-selective AMPAR inhibitor JNJ-55511118 on GluA2(Q) receptors expressed in HEK cells.
Journal ArticleDOI
Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects
TL;DR: A review of AMPA receptor ligands can be found in this paper , where the structural diversity of new chemotypes of agonists, competitive AMPA receptors, positive and negative allosteric modulators, transmembrane AMPA regulatory protein (TARP) dependent allosterics, ion channel blockers as well as their binding sites are discussed.
Journal ArticleDOI
The many faces of the AMPA-type ionotropic glutamate receptor
TL;DR: For instance, the authors provides a series of issues dedicated to each member of the Glutamate receptor superfamily that includes both ionotropic and metabotropic classes, including NMDA, AMPA-and kainate-selective iGluRs.
References
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Journal ArticleDOI
Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain.
TL;DR: It is shown that the extracellular AMPAR N-terminal domain (NTD), which projects midway into the synaptic cleft, plays a fundamental role in this process and mediates synaptic anchoring in a subunit-selective manner.
Journal ArticleDOI
Discovery and characterization of AMPA receptor modulators selective for TARP-γ8
Michael P. Maher,Nyantsz Wu,Suchitra Ravula,Michael K. Ameriks,Brad M. Savall,Changlu Liu,Brian Lord,Ryan M Wyatt,Jose A. Matta,Christine Dugovic,Sujin Yun,Luc Ver Donck,Thomas Steckler,Alan D. Wickenden,Nicholas I. Carruthers,Timothy W. Lovenberg +15 more
TL;DR: Novel AMPA receptor modulators that require the presence of the accessory protein CACNG8 are described that possess a novel mechanism of action consistent with a partial disruption of the interaction between the TARP and the pore-forming subunit of the channel.
Journal ArticleDOI
Defined criteria for auxiliary subunits of glutamate receptors.
Dan Yan,Susumu Tomita +1 more
TL;DR: Precise identification of auxiliary subunits and reconstruction of native glutamate receptors will open new directions to understanding the brain and its functions.
Journal ArticleDOI
Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity.
Remco V. Klaassen,Jasper Stroeder,Françoise Coussen,Françoise Coussen,Anne-Sophie Hafner,Anne-Sophie Hafner,Jennifer D. Petersen,Jennifer D. Petersen,Cedric Renancio,Cedric Renancio,Leanne J. M. Schmitz,Elisabeth Normand,Elisabeth Normand,Johannes C. Lodder,Diana C. Rotaru,Priyanka Rao-Ruiz,Sabine Spijker,Huibert D. Mansvelder,Daniel Choquet,Daniel Choquet,August B. Smit +20 more
TL;DR: It is shown that Shisa6 increases rise and decay times of hippocampal CA1 miniature excitatory postsynaptic currents (mEPSCs) and prevents synaptically trapped AMPARs from depression at high-frequency synaptic transmission.
Journal ArticleDOI
Structural basis of kainate subtype glutamate receptor desensitization
Joel R. Meyerson,Sagar Chittori,Alan Merk,Prashant Rao,Tae Hee Han,Mihaela Serpe,Mark L. Mayer,Sriram Subramaniam +7 more
TL;DR: It is shown that desensitization is characterized by the establishment of a ring-like structure in the ligand-binding domain layer of the receptor, mediated by staggered helix contacts between adjacent subunits, which leads to a pseudo-four-fold symmetric arrangement of the lig and-binding domains, illustrating subtle changes in symmetry that are important for the gating mechanism.