Journal ArticleDOI
Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity.
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TLDR
An overview of the catalogue of AMPAR interacting proteins and how they contribute to the complex biology of this central glutamate receptor can be found in this article, where an array of transmembrane proteins operate as auxiliary subunits that in addition to receptor trafficking and stabilization also substantially impact AMPAR gating and pharmacology.About:
This article is published in Neuropharmacology.The article was published on 2021-07-13. It has received 11 citations till now. The article focuses on the topics: Ionotropic glutamate receptor & AMPA receptor.read more
Citations
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Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance
TL;DR: In this paper , a patch-clamp electrophysiological recording from heterologously expressed AMPARs was used to characterize the actions of the γ8-selective AMPAR inhibitor JNJ-55511118 on GluA2(Q) receptors expressed in HEK cells.
Journal ArticleDOI
Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects
TL;DR: A review of AMPA receptor ligands can be found in this paper , where the structural diversity of new chemotypes of agonists, competitive AMPA receptors, positive and negative allosteric modulators, transmembrane AMPA regulatory protein (TARP) dependent allosterics, ion channel blockers as well as their binding sites are discussed.
Journal ArticleDOI
The many faces of the AMPA-type ionotropic glutamate receptor
TL;DR: For instance, the authors provides a series of issues dedicated to each member of the Glutamate receptor superfamily that includes both ionotropic and metabotropic classes, including NMDA, AMPA-and kainate-selective iGluRs.
References
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Journal ArticleDOI
The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development
Sampath Kumar Vemula,Ayse Malci,Lennart Junge,Anne-Christin Lehmann,Ramya Rama,Johannes Hradsky,Ricardo A. Matute,André Weber,Matthias Prigge,Michael Naumann,Michael R. Kreutz,Michael R. Kreutz,Constanze I. Seidenbecher,Eckart D. Gundelfinger,Eckart D. Gundelfinger,Rodrigo Herrera-Molina +15 more
TL;DR: A spinogenic mechanism that operates during neuronal development and is based on the interaction of tumor necrosis factor receptor-associated factor 6 (TRAF6) with the synaptic cell adhesion molecule neuroplastin is reported.
Journal ArticleDOI
Impaired AMPA receptor trafficking by a double knockout of zebrafish olfactomedin1a/b
TL;DR: Olfm1 may be considered a novel regulator of the composition and function of the α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptor complex.
Journal ArticleDOI
PORCN Negatively Regulates AMPAR Function Independently of Subunit Composition and the Amino-Terminal and Carboxy-Terminal Domains of AMPARs.
Mengping Wei,Mengping Wei,Meng Wang,Jue Wang,Feng Su,Feng Su,Yangzhen Wang,Yangzhen Wang,Meng Sun,Shanshan Wang,Shanshan Wang,Liu Mengna,Liu Mengna,Hongyi Wang,Mingyang Lu,Wei Li,Yutian Gong,Lei Yang,Chen Zhang,Chen Zhang +19 more
TL;DR: PORCN inhibited glutamate-induced currents and the surface expression of investigated GluA AMPAR subunits in a subunit-independent manner, and the functional inhibition of AMPARs by PORCN in transfected heterologous cells was independent of the ATD, CTD, and subunit composition of AM PARs.
Posted ContentDOI
AMPA receptor anchoring at CA1 synapses is determined by an interplay of N-terminal domain and TARP γ8 interactions
TL;DR: The data support a model in which γ8 accumulates AMPARs at the postsynaptic density, where the NTD further tunes their positioning, and interplay between cytosolic (γ8) and synaptic cleft (NTD) interactions provides versatility to regulate synaptic transmission and plasticity.
Journal ArticleDOI
Olfactomedin-3 Enhances Seizure Activity by Interacting With AMPA Receptors in Epilepsy Models.
Shirong Tang,Tiancheng Wang,Xiaogang Zhang,Yi Guo,Ping Xu,Junwei Zeng,Zhong Luo,Dongxu Li,Yongsu Zheng,Yuemei Luo,Changyin Yu,Zucai Xu +11 more
TL;DR: Findings reveal that OLFM3 may enhance seizure activity by interacting with GluA1 and GLUA2, potentially indicating a molecular mechanism for new therapeutic strategies.