Journal ArticleDOI
Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity.
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TLDR
An overview of the catalogue of AMPAR interacting proteins and how they contribute to the complex biology of this central glutamate receptor can be found in this article, where an array of transmembrane proteins operate as auxiliary subunits that in addition to receptor trafficking and stabilization also substantially impact AMPAR gating and pharmacology.About:
This article is published in Neuropharmacology.The article was published on 2021-07-13. It has received 11 citations till now. The article focuses on the topics: Ionotropic glutamate receptor & AMPA receptor.read more
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Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
Danyang Zhang,Remigijus Lape,Saher A. Shaikh,Bianka Kőhegyi,Jake F. Watson,Ondrej Cais,Terunaga Nakagawa,Ingo H. Greger +7 more
TL;DR: In this article , the authors determined the structures of the GluA1/2-γ8 receptor associated with three potent, chemically diverse ligands and found that despite sharing a lipid-exposed and water-accessible binding pocket, drug action is differentially affected by binding-site mutants.
Posted ContentDOI
Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics
TL;DR: In this article , the authors determined the structures of the GluA1/2-γ8 receptor associated with three potent, chemically diverse drugs and found that despite sharing a lipid-exposed and water-accessible binding pocket, drug action is differentially affected by binding-site mutants.
Journal ArticleDOI
NMDA receptor functions in health and disease: Old actor, new dimensions
TL;DR: In this article , newly discovered dimensions of postsynaptic NMDAR signaling supporting neural plasticity and cognition, such as the nanoscale organization of N-Methyl-D-aspartate ionotropic glutamate receptors, their activity-dependent redistributions, and non-ionotropic signaling capacities are reviewed.
Posted ContentDOI
Phototriggered profiling of receptor-proximal proteins in vivo in minutes
TL;DR: In this article, a photooxidation-driven proximity labeling for protein identification was proposed to identify characteristic as well as less studied interactors of the endogenous α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and the ψ-aminobutyric acid type A receptor (GABAAR).
Journal ArticleDOI
New Allosteric Modulators of AMPA Receptors: Synthesis and Study of Their Functional Activity by Radioligand-Receptor Binding Analysis
E. A. Golubeva,Mstislav I. Lavrov,Polina N. Veremeeva,T. V. Vyunova,Maxim A. Topchiy,Andrey F. Asachenko,Vladimir A. Palyulin +6 more
TL;DR: In this article , the synthesis of three new AMPA receptor modulators, derived from derivatives of 1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13]tetradecane-4,8,12-trione, was studied by radioligand-receptor binding analysis using PAM-43 as a reference ligand.
References
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Journal ArticleDOI
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Stephen F. Traynelis,Lonnie P. Wollmuth,Chris J. McBain,Frank S. Menniti,Katie M. Vance,Kevin K. Ogden,Kasper B. Hansen,Hongjie Yuan,Scott J. Myers,Raymond Dingledine +9 more
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
Journal ArticleDOI
AMPA Receptor Trafficking and Synaptic Plasticity
TL;DR: The growing literature that supports a critical role for AMPA receptors trafficking in LTP and LTD is reviewed, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins.
Journal ArticleDOI
A rapid and robust method for single cell chromatin accessibility profiling
Xi Chen,Ricardo J. Miragaia,Ricardo J. Miragaia,Kedar Nath Natarajan,Sarah A. Teichmann,Sarah A. Teichmann +5 more
TL;DR: A simple and robust plate-based single-cell ATAC-seq method that works in fresh and cryopreserved cells and identifies distinct immune cell types and reveal cell type-specific regulatory regions and related transcription factors is developed.
Journal ArticleDOI
Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia.
Sarosh R. Irani,Sian K Alexander,Patrick Waters,Kleopas A. Kleopa,Philippa Pettingill,Luigi Zuliani,Elior Peles,Camilla Buckley,B Lang,Angela Vincent +9 more
TL;DR: The identification of leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 as the major targets of potassium channel antibodies, and their associations with different clinical features, begins to explain the diversity of these syndromes.
Journal ArticleDOI
Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Lu Chen,Dane M. Chetkovich,Ronald S. Petralia,Neal T. Sweeney,Yoshimi Kawasaki,Robert J. Wenthold,David S. Bredt,Roger A. Nicoll +7 more
TL;DR: Stargazer, an ataxic and epileptic mutant mouse, lacks functional AMPA receptors on cerebellar granule cells, and expression of a mutant stargazin lacking the PDZ-binding domain in hippocampal pyramidal cells disrupts synaptic AMPA receptor receptors, indicating that st argazin-like mechanisms for targeting AM PA receptors may be widespread in the central nervous system.