Journal ArticleDOI
Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity.
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TLDR
An overview of the catalogue of AMPAR interacting proteins and how they contribute to the complex biology of this central glutamate receptor can be found in this article, where an array of transmembrane proteins operate as auxiliary subunits that in addition to receptor trafficking and stabilization also substantially impact AMPAR gating and pharmacology.About:
This article is published in Neuropharmacology.The article was published on 2021-07-13. It has received 11 citations till now. The article focuses on the topics: Ionotropic glutamate receptor & AMPA receptor.read more
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Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance
TL;DR: In this paper , a patch-clamp electrophysiological recording from heterologously expressed AMPARs was used to characterize the actions of the γ8-selective AMPAR inhibitor JNJ-55511118 on GluA2(Q) receptors expressed in HEK cells.
Journal ArticleDOI
Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects
TL;DR: A review of AMPA receptor ligands can be found in this paper , where the structural diversity of new chemotypes of agonists, competitive AMPA receptors, positive and negative allosteric modulators, transmembrane AMPA regulatory protein (TARP) dependent allosterics, ion channel blockers as well as their binding sites are discussed.
Journal ArticleDOI
The many faces of the AMPA-type ionotropic glutamate receptor
TL;DR: For instance, the authors provides a series of issues dedicated to each member of the Glutamate receptor superfamily that includes both ionotropic and metabotropic classes, including NMDA, AMPA-and kainate-selective iGluRs.
References
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Journal ArticleDOI
JNK3 Couples the Neuronal Stress Response to Inhibition of Secretory Trafficking
Guang Yang,Xun Zhou,Jingyan Zhu,Rui Liu,Si Zhang,Ainsley Coquinco,Yongting Chen,Yanhua Wen,Luba Kojic,William Jia,Max S. Cynader +10 more
TL;DR: The results suggest that JNK3 participates in an adaptive response to neuronal hyperexcitation by impeding secretory trafficking at the Golgi complex, which is critical for neuronal development, function, and stress response.
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Epileptic encephalopathy with continuous spike-and-wave during sleep maps to a homozygous truncating mutation in AMPA receptor component FRRS1L.
TL;DR: An updated pedigree of the original family shows that CSWS presents with seizures, usually focal-clonic and out of sleep, and neurocognitive regression, and the differential diagnosis includes Landau-Kleffner.
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Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain.
Lyndsey M. Kirk,Shu W. Ti,Hannah I. Bishop,Mayra Orozco-Llamas,Michelle Pham,James S. Trimmer,Elva D Diaz +6 more
TL;DR: The results indicate that, although SynDIG4 shares sequence similarity with SynDig1, it might act through a unique mechanism as an auxiliary factor for extrasynaptic GluA1‐containing AMPARs.
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Ferric Chelate Reductase 1 Like Protein (FRRS1L) Associates with Dynein Vesicles and Regulates Glutamatergic Synaptic Transmission
TL;DR: Describing FRRS1L in heterologous cells and neurons reveals an important role of FRRS 1L in the regulation of excitatory synaptic strength and strongly reduces the expression levels of the GluA1 subunit at the neuronal surface.
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Characterizing the binding and function of TARP γ8-selective AMPA receptor modulators.
TL;DR: Functional data reveal parallels in the underlying modulatory action of two prominent compounds that will aid development of refined AMPAR epilepsy therapeutics and facilitate to uncover the mechanisms by which TARPs modulate the receptor.