Journal ArticleDOI
Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity.
Reads0
Chats0
TLDR
An overview of the catalogue of AMPAR interacting proteins and how they contribute to the complex biology of this central glutamate receptor can be found in this article, where an array of transmembrane proteins operate as auxiliary subunits that in addition to receptor trafficking and stabilization also substantially impact AMPAR gating and pharmacology.About:
This article is published in Neuropharmacology.The article was published on 2021-07-13. It has received 11 citations till now. The article focuses on the topics: Ionotropic glutamate receptor & AMPA receptor.read more
Citations
More filters
Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Mechanisms underlying TARP modulation of the GluA1/2-γ8 AMPA receptor
Beatriz Herguedas,Bianka Kőhegyi,Jan-Niklas Dohrke,Jake F. Watson,Danyang Zhang,Hinze Ho,Saher A. Shaikh,Remigijus Lape,James Krieger,Ingo H. Greger +9 more
TL;DR: In this paper , electron cryo-microscopy structures of the GluA1/2 TARP-γ8 complex, in both open and desensitized states (at 3.5 Å), reveal state-selective engagement of the LBDs by the large TARPγ8 loop ('β1'), elucidating how this TARP stabilizes specific gating states.
Journal ArticleDOI
Influence of the TARP γ8-Selective Negative Allosteric Modulator JNJ-55511118 on AMPA Receptor Gating and Channel Conductance
TL;DR: In this paper , a patch-clamp electrophysiological recording from heterologously expressed AMPARs was used to characterize the actions of the γ8-selective AMPAR inhibitor JNJ-55511118 on GluA2(Q) receptors expressed in HEK cells.
Journal ArticleDOI
Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects
TL;DR: A review of AMPA receptor ligands can be found in this paper , where the structural diversity of new chemotypes of agonists, competitive AMPA receptors, positive and negative allosteric modulators, transmembrane AMPA regulatory protein (TARP) dependent allosterics, ion channel blockers as well as their binding sites are discussed.
Journal ArticleDOI
The many faces of the AMPA-type ionotropic glutamate receptor
TL;DR: For instance, the authors provides a series of issues dedicated to each member of the Glutamate receptor superfamily that includes both ionotropic and metabotropic classes, including NMDA, AMPA-and kainate-selective iGluRs.
References
More filters
Journal ArticleDOI
The LGI1–ADAM22 protein complex directs synapse maturation through regulation of PSD-95 function
Kathryn L. Lovero,Yuko Fukata,Yuko Fukata,Adam J. Granger,Masaki Fukata,Masaki Fukata,Roger A. Nicoll +6 more
TL;DR: It is demonstrated that leucine-rich, glioma-inactivated protein 1 (LGI1), a secreted protein previously shown to modulate synaptic AMPA receptors, is a paracrine signal released from pre- and post synapse neurons that acts specifically through a disintegrin and metalloproteinase protein 22 (ADAM22) to set postsynaptic strength.
Journal ArticleDOI
Lengthening of the stargazin cytoplasmic tail increases synaptic transmission by promoting interaction to deeper domains of PSD-95
Anne-Sophie Hafner,Andrew C. Penn,Andrew C. Penn,Dolors Grillo-Bosch,Dolors Grillo-Bosch,Natacha Retailleau,Natacha Retailleau,Christel Poujol,Amandine Philippat,Amandine Philippat,Françoise Coussen,Françoise Coussen,Matthieu Sainlos,Matthieu Sainlos,Patricio Opazo,Daniel Choquet,Daniel Choquet +16 more
TL;DR: This study finds that enhancing the apparent length of stargazin C-tail through phosphorylation or by an artificial linker was sufficient to potentiate binding to PSD-95, AMPAR anchoring, and synaptic transmission.
Journal ArticleDOI
Architecture of the heteromeric GluA1/2 AMPA receptor in complex with the auxiliary subunit TARP γ8
TL;DR: Cryo–electron microscopy is used to determine the structure of the most prevalent form of AMPAR in the hippocampus, the GluA1/2 heteromer in complex with its regulatory subunit TARPγ8, and provides insight into how conductance is controlled and modulated by auxiliary subunits.
Journal ArticleDOI
Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development
Hanqing Li,Ash Watson,Agnieszka Olechwier,Michael Anaya,Siamak K Sorooshyari,Dermott P Harnett,Hyung-Kook Peter Lee,Jost Vielmetter,Mario A. Fares,Mario A. Fares,K. Christopher Garcia,Engin Özkan,Juan-Pablo Labrador,Kai Zinn +13 more
TL;DR: A new method for interactome screening, the Bio-Plex Interactome Assay (BPIA), is described, which allows identification of many interactions in a single sample and suggests that Beats are neuronal receptors for Sides expressed on peripheral tissues.
Journal ArticleDOI
Cornichon-2 Modulates AMPA Receptor–Transmembrane AMPA Receptor Regulatory Protein Assembly to Dictate Gating and Pharmacology
TL;DR: Data suggest that CNIH-2 modulates neuronal AMPA receptor auxiliary subunit assembly by regulating the number of TARPs within an AMPA receptors complex to modulate receptor gating and pharmacology.