Book ChapterDOI
Biosynthesis and biological functions of terpenoids in plants
TLDR
This chapter gives an overview and highlights recent advances in the understanding of the organization, regulation, and diversification of core and specialized terpenoid metabolic pathways, and addresses the most important functions of volatile and nonvolatile terpenoids specialized metabolites in plants.Abstract:
Terpenoids (isoprenoids) represent the largest and most diverse class of chemicals among the myriad compounds produced by plants. Plants employ terpenoid metabolites for a variety of basic functions in growth and development but use the majority of terpenoids for more specialized chemical interactions and protection in the abiotic and biotic environment. Traditionally, plant-based terpenoids have been used by humans in the food, pharmaceutical, and chemical industries, and more recently have been exploited in the development of biofuel products. Genomic resources and emerging tools in synthetic biology facilitate the metabolic engineering of high-value terpenoid products in plants and microbes. Moreover, the ecological importance of terpenoids has gained increased attention to develop strategies for sustainable pest control and abiotic stress protection. Together, these efforts require a continuous growth in knowledge of the complex metabolic and molecular regulatory networks in terpenoid biosynthesis. This chapter gives an overview and highlights recent advances in our understanding of the organization, regulation, and diversification of core and specialized terpenoid metabolic pathways, and addresses the most important functions of volatile and nonvolatile terpenoid specialized metabolites in plants.read more
Citations
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Journal ArticleDOI
Oxidative Cyclization in Natural Product Biosynthesis
TL;DR: This Review examines the different strategies used by nature to create new intra(inter)molecular bonds via redox chemistry, with an emphasis on the former.
Journal ArticleDOI
Terpenes and isoprenoids: a wealth of compounds for global use.
TL;DR: This review summarizes features and applications of terpene and isoprenoid compounds, comprising the largest class of secondary metabolites, and finds application in pharmaceutical, nutraceutical, synthetic chemistry, flavor fragrance, and possibly biofuel industries.
Journal ArticleDOI
Terpene synthases from Cannabis sativa
TL;DR: Functional characterization identified mono- and sesqui-TPS, whose products collectively comprise most of the terpenes of ‘Finola’ resin, including major compounds such as β-myrcene, (E)-β-ocimene, (-)-limonene, (+)-α-pinene, β-caryophyllene, and α-humulene.
Journal ArticleDOI
Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid Chemical Diversity.
TL;DR: Current knowledge on the functional diversity and molecular evolution of the plant TPS family that underlies the chemical diversity of bioactive terpenoids across the plant kingdom is reviewed.
Journal ArticleDOI
Volatile terpenoids: multiple functions, biosynthesis, modulation and manipulation by genetic engineering
Farhat Abbas,Yanguo Ke,Rangcai Yu,Yuechong Yue,Sikandar Amanullah,Muhammad Muzammil Jahangir,Yanping Fan +6 more
TL;DR: This review summarizes the recent advances in biosynthetic pathways, including the spatiotemporal, transcriptional and post-transcriptional regulatory mechanisms, and discusses the multiple functions of the terpene synthase genes (TPS), their interaction with the surrounding environment and the use of genetic engineering for terpenoid production in model plants.
References
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Journal ArticleDOI
Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi
TL;DR: Strigolactones are a group of sesquiterpene lactones, previously isolated as seed-germination stimulants for the parasitic weeds Striga and Orobanche, and a synthetic analogue, GR24, induced extensive hyphal branching in germinating spores of the AM fungus Gigaspora margarita at very low concentrations.
Journal ArticleDOI
Strigolactone inhibition of shoot branching
Victoria Gomez-Roldan,Victoria Gomez-Roldan,Soraya Fermas,Philip B. Brewer,Virginie Puech-Pagès,Virginie Puech-Pagès,Elizabeth A. Dun,Jean-Paul Pillot,Fabien Létisse,Radoslava Matusova,Saida Danoun,Saida Danoun,Jean-Charles Portais,Harro J. Bouwmeester,Guillaume Bécard,Guillaume Bécard,Christine A. Beveridge,Catherine Rameau,Soizic Rochange,Soizic Rochange +19 more
TL;DR: Evidence is presented that carotenoid cleavage dioxygenase 8 shoot branching mutants of pea are strigolactone deficient and that strigOLactone application restores the wild-type branching phenotype to ccd8 mutants, and that other branching mutants previously characterized as lacking a response to the branching inhibition signal also lack striglactone response.
Journal ArticleDOI
The 1-deoxy-d-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants
TL;DR: The DOXP pathway of IPP formation starts from D-glyceraldehyde-3-phosphate and pyruvate, with DOXP-synthase as the starting enzyme, and provides new insight into the regulation of chloroplast metabolism.
Journal ArticleDOI
Recruitment of entomopathogenic nematodes by insect-damaged maize roots
Sergio Rasmann,Tobias G. Köllner,Jörg Degenhardt,Ivan Hiltpold,Stefan Toepfer,Ulrich Kuhlmann,Jonathan Gershenzon,Ted C. J. Turlings +7 more
TL;DR: The first identification of an insect-induced belowground plant signal, (E)-β-caryophyllene, which strongly attracts an entomopathogenic nematode, is reported, which should help enhance the efficacy of nematodes as biological control agents against root pests like D. virgifera.
Journal ArticleDOI
Inhibitors of the Nonmevalonate Pathway of Isoprenoid Biosynthesis as Antimalarial Drugs
Hassan Jomaa,Jochen Wiesner,Silke Sanderbrand,Boran Altincicek,Claus Weidemeyer,Martin Hintz,Ivana Türbachova,Matthias Eberl,Johannes Zeidler,Hartmut K. Lichtenthaler,Dominique Soldati,Ewald Beck +11 more
TL;DR: A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective target for chemotherapy of malaria and the presence of two genes encoding the enzymes DOXP synthase and DOXP reductoisomerase suggests that isoprene biosynthesis in P. falcIParum depends on the DOXP pathway.