Journal ArticleDOI
Botulinum a neurotoxin inhibits non-cholinergic synaptic transmission in mouse spinal cord neurons in culture
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TLDR
It is demonstrated, for the first time using electrophysiological techniques, that botulinum A neurotoxin blocks both excitatory and inhibitory synaptic transmission in the mammalian central nervous system.About:
This article is published in Brain Research.The article was published on 1985-12-23. It has received 134 citations till now. The article focuses on the topics: Neurotoxin & Inhibitory postsynaptic potential.read more
Citations
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Journal ArticleDOI
Properties and use of botulinum toxin and other microbial neurotoxins in medicine.
TL;DR: Crystalline botulinum toxin type A was licensed in December 1989 by the Food and Drug Administration for treatment of certain spasmodic muscle disorders following 10 or more years of experimental treatment on human volunteers and its chemical, physical, and biological properties as applied to its use in medicine are described.
Journal ArticleDOI
Structure and function of tetanus and botulinum neurotoxins
TL;DR: Tetanus and botulinum neurotoxins form a new group of zinc-endopeptidases with characteristic sequence, mode of zinc coordination, mechanism of activation and target recognition, of great value in the unravelling of the mechanisms of exocytosis and endocytotic, as they are in the clinical treatment of dystonias.
Book ChapterDOI
Clostridial neurotoxins: handling and action at the cellular and molecular level.
E. Habermann,F. Dreyer +1 more
TL;DR: Tetanus and botulism have fascinated mankind since they were first described by Hippocrates and Kerner respectively, and no other group of toxins has aroused as much interest as the clostridial neurotoxins.
Journal ArticleDOI
Clostridial Neurotoxins and Substrate Proteolysis in Intact Neurons BOTULINUM NEUROTOXIN C ACTS ON SYNAPTOSOMAL-ASSOCIATED PROTEIN OF 25 kDa
TL;DR: In this paper, the authors used immunohistochemistry and immunoblotting to demonstrate alterations in toxin substrates in intact neurons under conditions of toxin-induced blockade of neurotransmitter release.
Patent
Methods for treating pain
Kei Roger Aoki,Minglei Cui +1 more
TL;DR: In this paper, methods for treating pain by intrathecal administration to a human patient of a therapeutically effective amount of a neurotoxin such as botulinum toxin type A are disclosed.
References
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Journal ArticleDOI
Mouse spinal cord in cell culture. I. Morphology and intrinsic neuronal electrophysiologic properties.
TL;DR: Reliable methods for establishing fetal mouse spinal cord and dorsal root ganglion cells in long term (greater than 1 mo) dissociated cell cultures are described and current-voltage relationships and linear electrotonic properties of the neurons are described.
Journal ArticleDOI
Tetanus toxin and botulinum A toxin inhibit release and uptake of various transmitters, as studied with particulate preparations from rat brain and spinal cord.
TL;DR: It is proposed that tetanus and botulinum A toxin act in a basically similar manner on a process underlying the function of synapses in general, and the pronounced sensitivity of glycine and GABA release from spinal cord, together with the axonal ascent of tetanus toxin, may be crucial in the pathogenesis of tetanos.
Journal ArticleDOI
Tetanus toxin blocks the neuromuscular transmission in vitro like botulinum A toxin.
TL;DR: The paralysis is produced by tetanus toxin itself and not by contaminants as shown by the parallel decrease of toxicity and paralysis following treatment with either antitoxin or brain homogenate, or by the use of spontaneously inactivated toxin.