Journal ArticleDOI
Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity.
Thomas Pons,Emilie Pic,Nicolas Lequeux,Elsa Cassette,Lina Bezdetnaya,François Guillemin,Frédéric Marchal,Benoit Dubertret +7 more
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TLDR
The synthesis of CuInS(2)/ZnS core/shell QDs emitting in the NIR with good quantum yield and stability even after transfer into water is presented and compared to their Cd-containing counterparts to show a clear difference in acute local toxicity.Abstract:
Semiconductor quantum dots (QDs) could significantly impact the performance of biomedical near-infrared (NIR) imaging by providing fluorescent probes that are brighter and more photostable than conventional organic dyes. However, the toxicity of the components of NIR emitting II−VI and IV−VI QDs that have been made so far (Cd, Hg, Te, Pb, etc.) has remained a major obstacle to the clinical use of QDs. Here, we present the synthesis of CuInS2/ZnS core/shell QDs emitting in the NIR (∼800 nm) with good quantum yield and stability even after transfer into water. We demonstrate the potential of these QDs by imaging two regional lymph nodes (LNs) in vivo in mice. We then compare the inflammatory response of the axillary LN induced by different doses of CuInS2/ZnS and CdTeSe/CdZnS QDs and show a clear difference in acute local toxicity, the onset of inflammation only occurring at a 10 times more concentrated dose for CuInS2/ZnS QDs than for their Cd-containing counterparts.read more
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Copper selenide nanocrystals for photothermal therapy.
Colin M. Hessel,Varun P. Pattani,Michael R. Rasch,Matthew G. Panthani,Bonil Koo,James W. Tunnell,Brian A. Korgel +6 more
TL;DR: In vitro photothermal heating of Cu(2-x)Se nanocrystals in the presence of human colorectal cancer cell (HCT-116) led to cell destruction after 5 min of laser irradiation at 33 W/cm(2), demonstrating the viabilitiy of Cu
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Nanomaterials: Applications in Cancer Imaging and Therapy
TL;DR: A brief description of cancer pathology and the characteristics that are important for tumor‐targeted NM design are provided, followed by an overview of the different types of NMs explored to date, covering synthetic aspects and approaches explored.
Journal ArticleDOI
Efficient synthesis of highly luminescent copper indium sulfide-based core/shell nanocrystals with surprisingly long-lived emission
Liang Li,Anshu Pandey,Donald J. Werder,Bishnu P. Khanal,Jeffrey M. Pietryga,Victor I. Klimov +5 more
TL;DR: On the basis of time-resolved spectroscopic studies of core/shell particles, it is concluded that the emission is due to an optical transition that couples a quantized electron state to a localized hole state, which is most likely associated with an internal defect.
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Compound Copper Chalcogenide Nanocrystals
TL;DR: This review captures the synthesis, assembly, properties, and applications of copper chalcogenide NCs, which have achieved significant research interest in the last decade due to their compositional and structural versatility.
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Dependence of Nanoparticle Toxicity on Their Physical and Chemical Properties.
Alyona Sukhanova,Alyona Sukhanova,S V Bozrova,Pavel Sokolov,Mikhail A. Berestovoy,Alexander Karaulov,Igor Nabiev,Igor Nabiev +7 more
TL;DR: This review systematizes and summarizes available data on how the mechanisms of NP toxicity for living systems are related to their physical and chemical properties.
References
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Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
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Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles
TL;DR: Results of older bio-kinetic studies with NSPs and newer epidemiologic and toxicologic studies with airborne ultrafine particles can be viewed as the basis for the expanding field of nanotoxicology, which can be defined as safety evaluation of engineered nanostructures and nanodevices.
Journal ArticleDOI
Quantum dot bioconjugates for imaging, labelling and sensing
TL;DR: This review looks at current methods for preparing QD bioconjugates as well as presenting an overview of applications, and concludes that the potential of QDs in biology has just begun to be realized and new avenues will arise as the ability to manipulate these materials improves.
Journal ArticleDOI
In vivo cancer targeting and imaging with semiconductor quantum dots
TL;DR: Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.
Journal ArticleDOI
Synthesis and Characterization of Monodisperse Nanocrystals and Close-Packed Nanocrystal Assemblies
TL;DR: In this article, solution phase syntheses and size-selective separation methods to prepare semiconductor and metal nanocrystals, tunable in size from ∼1 to 20 nm and monodisperse to ≤ 5%, are presented.