Journal ArticleDOI
Calbindin-D28K-containing neurons in animal models of neurodegeneration: possible protection from excitotoxicity
TLDR
The presence of CaBP28K may protect neurons from calcium-mediated neurotoxicity, and Immunocytochemical characterization of the substantia nigra of the MPTP-treated mice revealed that there was significant dopaminergic cell loss in this brain area after MPTP treatment.About:
This article is published in Molecular Brain Research.The article was published on 1992-04-01. It has received 196 citations till now. The article focuses on the topics: Substantia nigra & MPTP.read more
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The role of excitotoxicity in neurodegenerative disease: implications for therapy.
TL;DR: There now seems to be little doubt that such a process is indeed a determining factor in the extent of the lesions observed, and direct evidence for a pathogenic role for excitotoxicity in neurological disease is missing.
Journal ArticleDOI
The role of neuronal growth factors in neurodegenerative disorders of the human brain
Bronwen Connor,Mike Dragunow +1 more
TL;DR: The role members of the nerve growth factor family (NGF, BDNF and NT-3) and trk receptors as well as additional growth factors (GDNF, TGF-alpha and IGF-I) may play in neurodegenerative disorders of the human brain are examined.
Journal ArticleDOI
The relevance of iron in the pathogenesis of Parkinson's disease.
Jeswinder Sian-Hülsmann,Silvia Mandel,Moussa B. H. Youdim,Moussa B. H. Youdim,Peter Riederer +4 more
TL;DR: In this article, a host of putative mechanisms that might contribute to the pathogenesis underlying the characteristic degeneration of the dopaminergic neurons in the substantia nigra (SN) were investigated.
Journal ArticleDOI
Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF
TL;DR: The results suggest that several of the neurotrophins have important effects in the differentiation and maintenance of function of subpopulations of hippocampal neurons.
Journal ArticleDOI
The role of calcium‐binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis
Maria E. Alexianu,Bao‐Kuang ‐K Ho,A. Habib Mohamed,Vincenzo La Bella,R. Glenn Smith,Stanley H. Appel +5 more
TL;DR: In this article, the authors investigated whether calcium-binding proteins contribute to selective motoneuron vulnerability in ALS, and compared calbindin-D28K and parvalbumin immunoreactivity in motoneur populations in human ALS and in a ventral spinal cord hybrid cell line selectively vulnerable to the cytotoxic effects of ALS IgG.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
Journal ArticleDOI
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.
TL;DR: A simple and rapid method for transferring RNA from agarose gels to nitrocellulose paper for blot hybridization has been developed, allowing removal of the hybridized probes and rehybridization of the RNA blots without loss of sensitivity.
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Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose
Haim Aviv,Philip Leder +1 more
TL;DR: A convenient technique for the partial purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described and should prove generally useful as an initial step in the isolation of specific mRNAs.