Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary.
Fritz A. Tschopp,Hermann Henke,Josef B. Petermann,Paul H. Tobler,Robert Janzer,Tomas Hökfelt,Jan M. Lundberg,Claudio Cuello,Jan A. Fischer +8 more
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TLDR
In the ventral part of the spinal cord as well as in the pituitary and thyroid glands, CGRP values were higher when measured by radioreceptorassay as compared to RIA, indicating that at least two C GRP-like components are present.Citations
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Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells.
G. Ju,Tomas Hökfelt,Ernst Brodin,Jan Fahrenkrug,Jan A. Fischer,Peter Frey,Robert Elde,John C. Brown +7 more
TL;DR: The present results indicate that a CGRP-like peptide is present in a wide range of primary sensory neurons probably not related to specific sensory modalities and often this peptide coexists with other biologically active peptides.
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Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
Z. Wiesenfeld-Hallin,Tomas Hökfelt,Jan M. Lundberg,W.G. Forssmann,M. Reinecke,Fritz A. Tschopp,Jan A. Fischer +6 more
TL;DR: Analysis of caudally directed biting and scratching behavior after intrathecal administration of CGRP and SP alone or in combination provides support for a possible interaction of the two peptides at synapses in the dorsal horn of the spinal cord.
Journal ArticleDOI
Neuroanatomical Localization, Pharmacological Characterization and Functions of CGRP, Related Peptides and Their Receptors
TL;DR: Findings on the anatomical distributions of CGRP mRNA, C GRP-like immunoreactivity and receptors in the central nervous system, as well as the potential physiological roles for CGRp are discussed.
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Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro
TL;DR: It is reported that human pancreatic amylin and rat CGRP-1 are potent inhibitors of both basal and insulin-stimulated rates of glycogen synthesis in stripped rat soleus muscle in vitro, which may provide a basis for a new understanding of the molecular mechanisms that cause insulin resistance in skeletal muscle.
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Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.
Geoffrey C. Nicholson,Jane M. Moseley,Patrick M. Sexton,Frederick A.O. Mendelsohn,Thomas J. Martin +4 more
TL;DR: It was found that greater than 80% of specifically bound radioactivity was associated with multinucleate osteoclasts and the remainder wasassociated with mononuclear cells that are not osteoblasts, but that may be osteoclast precursors.
References
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Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing
Michael G. Rosenfeld,Jean-Jacques Mermod,Susan G. Amara,Larry W. Swanson,Paul E. Sawchenko,Jean Rivier,Wylie Vale,Ronald M. Evans +7 more
TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
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Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products
TL;DR: A model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression is proposed.
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Detection of substance P in the central nervous system by a monoclonal antibody
TL;DR: A rat monoclonal antibody produced by a hybrid myeloma is reported and shown to bind specifically and with a remarkably low background to nerve terminals and cell bodies located in clearly defined nuclear organizations of the central nervous system.
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Isolation and characterization of human calcitonin gene-related peptide
TL;DR: The human peptide differs significantly from the predicted rat calcitonin gene-related peptide structure in four positions in the amino acid sequence (three effecting charge changes), and the presence of a disulphide bridge and an amide, surmised in the rat work, is proven in the hCGRP molecule as discussed by the authors.
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Stimulation of noradrenergic sympathetic outflow by calcitonin gene-related peptide.
Laurel A. Fisher,Don O. Kikkawa,Jean Rivier,Susan G. Amara,Ronald M. Evans,Michael G. Rosenfeld,Wylie Vale,Marvin R. Brown +7 more
TL;DR: It is reported here that CGRP acts in the central nervous system to stimulate selectively noradrenergic sympathetic outflow and is identified immunocytochemically throughout the central and peripheral nervous systems.