Journal ArticleDOI
Capsaicin and capsiate could be appropriate agents for treatment of obesity: A meta-analysis of human studies.
Csaba Zsiborás,Róbert Mátics,Péter Hegyi,Márta Balaskó,Erika Pétervári,Imre Szabó,Patrícia Sarlós,Alexandra Mikó,Judit Tenk,Ildikó Rostás,Dániel Pécsi,András Garami,Zoltan Rumbus,Orsolya Huszár,Margit Solymár +14 more
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TLDR
The data clearly suggest that capsaicin or capsiate could be a new therapeutic approach in obesity promoting a negative energy balance and increased fat oxidation.Abstract:
Consumption of capsaicin or its nonpungent analogues, capsinoids has been reported to affect energy expenditure and fat oxidation, although available data are still controversial. The aim of the present study was to conduct a meta-analysis regarding the effects of these substances on energy expenditure and respiratory quotient, with special emphasis on the role of body mass index (BMI) of the participants. Medical databases were systematically searched for papers. Of the 627 trials identified, 9 provided results suitable to be included in analysis. Data analysis showed that after ingestion of capsaicin or capsinoids the energy expenditure increased (245 kJ/day, 58.56 kcal/day, p = 0.030) and the respiratory quotient decreased (by 0.216; p = 0.031) indicating a rise in fat oxidation. Studies with mean BMI of the participants below 25 kg/m2 failed to report any effect of capsaicin or capsinoids on the energy expenditure (p = 0.718) or on the respiratory quotient (p = 0.444), but studies with mean BM...read more
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Involvement of thermosensitive TRP channels in energy metabolism.
Kunitoshi Uchida,Kunitoshi Uchida,Katsuya Dezaki,Takeshi Yoneshiro,Tatsuo Watanabe,Jun Yamazaki,Masayuki Saito,Toshihiko Yada,Makoto Tominaga,Yusaku Iwasaki +9 more
TL;DR: It is shown that capsaicin-induced adrenaline secretion is completely impaired in TRPV1 knockout mice, and thermo-TRPs are promising targets for combating obesity and metabolic disorders.
Journal ArticleDOI
Enhancing analgesic and anti-inflammatory effects of capsaicin when loaded into olive oil nanoemulsion: an in vivo study.
Zahra Ghiasi,Fariba Esmaeli,Mahdi Aghajani,Mahmoud Ghazi-Khansari,Mohammad Ali Faramarzi,Amir Amani +5 more
TL;DR: It was found that the topical gel outperforms the topical cream as dosage form for the nanoemulsion and showed great potential as carrier for topical delivery of capsaicin for improving its analgesic and anti‐inflammatory effects.
Journal ArticleDOI
Capsaicin-the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems.
Muwen Lu,Chengyu Chen,Yaqi Lan,Jie Xiao,Run Li,Junqing Huang,Qingrong Huang,Yong Cao,Chi-Tang Ho +8 more
TL;DR: This review provides a theoretical basis for capsaicin to be further developed into a multi-functional ingredient with health-promoting functions in the nutraceutical industry.
Journal ArticleDOI
Effects and mechanisms of edible and medicinal plants on obesity: an updated review
TL;DR: The anti-obesity activity of edible and medicinal plants was summarized based on epidemiological, experimental, and clinical studies, with related mechanisms discussed, which provided the basis for the research and development of slimming products.
Journal ArticleDOI
Molecular mechanisms of the anti-obesity effect of bioactive ingredients in common spices: a review
TL;DR: After oral treatment with the spice extracts, apoptosis was induced in 3T3-L1 cells, thermogenesis was promoted in adipose tissues, and there was decreased body weight gain in obese animal models and human participants, which provide the basis for these functional food compounds to be developed into dietary supplements against obesity.
References
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Journal ArticleDOI
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Michael J. Caterina,Mark Schumacher,Makoto Tominaga,Tobias A. Rosen,Jon D. Levine,David Julius +5 more
TL;DR: The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
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Prevalence and trends in obesity among US adults, 1999-2008.
TL;DR: The increases in the prevalence of obesity previously observed do not appear to be continuing at the same rate over the past 10 years, particularly for women and possibly for men.
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Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
TL;DR: Intervention in obesity, in addition to the well established risk factors, appears to be an advisable goal in the primary prevention of CVD.
Journal Article
Vanilloid (Capsaicin) Receptors and Mechanisms
Arpad Szallasi,Peter M. Blumberg +1 more
TL;DR: This paper focuses on hot pepper, which is eaten on a daily basis by an estimated one-quarter of the world’s population and has potential to be a biological target for regenerative medicine.
Journal Article
Prevalence of Obesity Among Adults and Youth: United States, 2011-2014.
TL;DR: This report provides the most recent national data on obesity prevalence by sex, age, and race and Hispanic origin, using data for 2011- 2014.