Journal ArticleDOI
Carbon monoxide from heme catabolism protects against hepatobiliary dysfunction in endotoxin-treated rat liver.
Takanori Kyokane,Shinji Norimizu,Hisashi Taniai,Tokio Yamaguchi,Shinji Takeoka,Eishun Tsuchida,Makoto Naito,Yuji Nimura,Yuzuru Ishimura,Makoto Suematsu +9 more
TLDR
Protective roles of CO against hepatobiliary dysfunction caused by heme overloading under stress conditions are suggested.About:
This article is published in Gastroenterology.The article was published on 2001-04-01. It has received 161 citations till now. The article focuses on the topics: Heme oxygenase & Heme.read more
Citations
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Journal ArticleDOI
Heme oxygenase-1: the "emerging molecule" has arrived.
TL;DR: This review highlights current information on the function of HO-1 and its relevance to specific pulmonary and cardiovascular diseases and shows its anti-inflammatory, antiapoptotic, and antiproliferative effects.
Journal ArticleDOI
The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair
TL;DR: The use of the recently introduced techniques to monitor the hepatic microcirculation in humans, such as near-infrared spectroscopy or orthogonal polarized spectral imaging, may allow an early initiation of treatment, which should benefit the final outcome of these critically ill patients.
Journal ArticleDOI
Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase.
Frank A. D. T. G. Wagener,Andreas O. Eggert,Otto Boerman,Wim J.G. Oyen,Albert A.J. Verhofstad,Nader G. Abraham,Gosse Jan Adema,Yvette van Kooyk,Theo de Witte,Carl G. Figdor +9 more
TL;DR: It is demonstrated for the first time that heme induces increased vascular permeability, adhesion molecule expression, and leukocyte recruitment in vivo, whereas HO antagonizes heme-induced inflammation possibly through the down-modulation of adhesion molecules.
Journal ArticleDOI
Heme oxygenase-1: redox regulation and role in the hepatic response to oxidative stress.
Michael Bauer,Inge Bauer +1 more
TL;DR: Evidence suggests that protective effects of up-regulation of the HO pathway--presumably through production of bile pigments and CO--have been reported for a variety of cells and tissues, including the liver, evidence suggests that the protective action might be restricted to a rather narrow threshold of overexpression.
Journal ArticleDOI
Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology.
TL;DR: This work takes an integrated approach to the interaction of gases by considering the physiological significance of CO, NO, CO, and H2S on mitochondrial cytochrome c oxidase, a key target and central mediator of mitochondrial respiration.
References
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Journal ArticleDOI
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group.
Paul C. Hébert,George A. Wells,Morris A. Blajchman,John C. Marshall,Claudio Martin,Giuseppe Pagliarello,Martin Tweeddale,Irwin Schweitzer,Elizabeth Yetisir +8 more
TL;DR: A restrictive strategy of red-cell transfusion is at least as effective as and possibly superior to a liberal transfusion strategy in critically ill patients, with the possible exception of patients with acute myocardial infarction and unstable angina.
Journal ArticleDOI
Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications.
TL;DR: In this review recent findings on heme oxygenase are highlighted and it is shown that the enzyme activity is inhibited in vivo for extended periods subsequent to binding of Zn- and Sn- protoporphyrins.
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Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
Akihiro Yachie,Yo Niida,Taizo Wada,Noboru Igarashi,Hisashi Kaneda,Tomoko Toma,Kazuhide Ohta,Yoshihito Kasahara,Shoichi Koizumi +8 more
TL;DR: The first known human case of heme oxygenase-1 (HO-1) deficiency is presented and clues to the key roles played by this important enzyme in vivo are provided.
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Heme oxygenase-1: function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury.
Augustine M.K. Choi,Jawed Alam +1 more
TL;DR: The magnitude ofHO-1 induction after oxidative stress and the wide distribution of this enzyme in systemic tissues coupled with the intriguing biological activities of the catalytic byproducts, carbon monoxide, iron, and bilirubin makes HO-1 a highly attractive and interesting candidate stress-response protein which may play key role(s) in mediating protection against oxidant-mediated lung injury.
Journal ArticleDOI
Heme oxygenase 1 is required for mammalian iron reutilization
Kenneth D. Poss,Susumu Tonegawa +1 more
TL;DR: Results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.