Journal ArticleDOI
Carbon nanotube-based ultrasensitive multiplexing electrochemical immunosensor for cancer biomarkers.
Ying Wan,Wangping Deng,Yan Su,Xinhua Zhu,Cheng Peng,Haiyan Hu,Hongzhen Peng,Shiping Song,Chunhai Fan,Chunhai Fan +9 more
TLDR
By using the SPCE array and the universal nanoprobe, the immunoassay system shows promising applications for in-field and point-of-care test in clinical diagnostics and demonstrates simultaneous detection of two protein biomarkers.About:
This article is published in Biosensors and Bioelectronics.The article was published on 2011-12-15. It has received 139 citations till now. The article focuses on the topics: Nanoprobe.read more
Citations
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Electrochemical Methods for the Analysis of Clinically Relevant Biomolecules
TL;DR: This Review summarizes advances from the past 5 years in the development of electrochemical sensors for clinically relevant biomolecules, including small molecules, nucleic acids, and proteins and addresses the remaining challenges and opportunities.
Journal ArticleDOI
Electrochemical Immunosensors for Detection of Cancer Protein Biomarkers
TL;DR: Recent developments in electrochemical immunosensors have significantly improved the sensitivity needed to detect low concentrations of biomarkers present in early stages of cancer, with an emphasis on opportunities for further improvement in cancer diagnostics and treatment monitoring.
Journal ArticleDOI
Screen-printed electrodes for biosensing: a review (2008–2013)
TL;DR: This review first gives an introduction into the topic of screen-printed electrodes for biosensing and is subdivided into sections (a) on DNA sensors, (b) on aptasensors, (c) on immunosensor, (d) on enzymatic biosensors.
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Carbon nanotubes: a novel material for multifaceted applications in human healthcare
TL;DR: The main focus of this review is to explore the maximum applications of CNTs for human health, and it particularly focus on nanocarrier and biomedical applications.
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Point of care testing: The impact of nanotechnology.
Leila Syedmoradi,Maryam S. Daneshpour,Mehrdad Alvandipour,Frank A. Gomez,Hassan Hajghassem,Kobra Omidfar +5 more
TL;DR: Present technologies in on-site or at home POC diagnostic assays implemented in paper-based microfluidic and screen printing devices over the past decade as well as in the near future are discussed.
References
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Journal ArticleDOI
The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay
A. E. Bolton,William M. Hunter +1 more
TL;DR: With some antisera the immunoreactivity of the antigen was diminished by the introduction of a single I atom into the tyrosyl groups, whereas antigen containing a single (125)I-labelled 3-(4-hydroxyphenyl)propionamide group showed the same immunore activity as the unmodified antigen.
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Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins.
TL;DR: An ultrasensitive method for detecting protein analytes has been developed and comparable clinically accepted conventional assays for detecting the same target have sensitivity limits of ∼3 picomdar, six orders of magnitude less sensitive than what is observed with this method.
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Biomarkers in cancer staging, prognosis and treatment selection.
TL;DR: Advances in genomics, proteomics and molecular pathology have generated many candidate biomarkers with potential clinical value, but how and when they can be integrated into clinical care is crucial.
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Phases of Biomarker Development for Early Detection of Cancer
Margaret S. Pepe,Ruth Etzioni,Ziding Feng,John D. Potter,Mary Lou Thompson,Mark D. Thornquist,Marcy Winget,Yutaka Yasui +7 more
TL;DR: The purpose of this commentary is to define a formal structure to guide the process of biomarker development and to provide a checklist of issues that should be addressed at each phase of development before proceeding to the next.
Journal Article
Serum Protein Fingerprinting Coupled with a Pattern-matching Algorithm Distinguishes Prostate Cancer from Benign Prostate Hyperplasia and Healthy Men
Bao Ling Adam,Yinsheng Qu,John W. Davis,Michael D. Ward,Mary Ann Clements,Lisa H. Cazares,O. John Semmes,Paul F. Schellhammer,Yutaka Yasui,Ziding Feng,George L. Wright,George L. Wright +11 more
TL;DR: A protein biochip surface enhanced laser desorption/ionization mass spectrometry approach coupled with an artificial intelligence learning algorithm to differentiate PCA from noncancer cohorts will provide a highly accurate and innovative approach for the early detection/diagnosis of PCA.