Journal ArticleDOI
Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial
Matthias Thielmann,Eva Kottenberg,Petra Kleinbongard,Daniel Wendt,Nilgün Gedik,Susanne Pasa,Vivien Price,Konstantinos Tsagakis,Markus Neuhäuser,Jürgen Peters,Heinz Jakob,Gerd Heusch +11 more
TLDR
Remote ischaemic preconditioning provided perioperative myocardial protection and improved the prognosis of patients undergoing elective CABG surgery.About:
This article is published in The Lancet.The article was published on 2013-08-17. It has received 429 citations till now. The article focuses on the topics: Coronary artery bypass surgery & Ischemic preconditioning.read more
Citations
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Journal ArticleDOI
Molecular Basis of Cardioprotection: Signal Transduction in Ischemic Pre-, Post-, and Remote Conditioning
TL;DR: The present review characterizes the signalTransduction underlying the conditioning phenomena, including their physical and chemical triggers, intracellular signal transduction, and effector mechanisms, notably in the mitochondria, as a highly concerted spatiotemporal program.
Journal ArticleDOI
Remote Ischemic Preconditioning and Outcomes of Cardiac Surgery.
Derek J. Hausenloy,Luciano Candilio,Richard Evans,Cono Ariti,David P. Jenkins,Shyam Kolvekar,Rosemary Knight,Gudrun Kunst,Chris Laing,Jennifer M. Nicholas,John Pepper,Steven Robertson,Maria Xenou,Tim Clayton,Derek M. Yellon +14 more
TL;DR: Remote ischemic preconditioning did not improve clinical outcomes in patients undergoing elective on-pump CABG with or without valve surgery and there were no significant between-group differences in either adverse events or the secondary end points of perioperative myocardial injury.
Journal ArticleDOI
Cardiovascular remodelling in coronary artery disease and heart failure
Gerd Heusch,Peter Libby,Bernard J. Gersh,Derek M. Yellon,Michael Böhm,Gary D. Lopaschuk,Lionel H. Opie +6 more
TL;DR: The remodelling processes in atherosclerosis, vascular and myocardial ischaemia-reperfusion injury, and heart failure are characterised, and potential avenues for innovative therapeutic approaches are drawn attention, including conditioning and metabolic strategies.
Journal ArticleDOI
A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery
Patrick Meybohm,Berthold Bein,Oana Brosteanu,Jochen Cremer,Matthias Gruenewald,Christian Stoppe,Mark Coburn,G. Schaelte,Andreas Böning,Bernd Niemann,Jan P. Roesner,Frank Kletzin,U. Strouhal,Christian Reyher,Rita Laufenberg-Feldmann,Marion Ferner,I. F. Brandes,Martin Bauer,Sebastian Stehr,Andreas Kortgen,Maria Wittmann,Georg Baumgarten,Tanja Meyer-Treschan,Peter Kienbaum,Matthias Heringlake,Julika Schön,Michael Sander,Sascha Treskatsch,Thorsten Smul,Ewa Wolwender,Thomas F. Schilling,Georg Fuernau,Dirk Hasenclever,Kai Zacharowski +33 more
TL;DR: Upper-limb RIPC performed while patients were under propofol-induced anesthesia did not show a relevant benefit among patients undergoing elective cardiac surgery.
Journal ArticleDOI
Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning
TL;DR: The critical need to take into account the presence of cardiovascular risk factors and concomitant medications when designing preclinical studies for the identification and validation of cardioprotective drug targets and clinical studies is emphasized.
References
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Journal ArticleDOI
Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion.
TL;DR: Brief episodes of ischemia in one vascular bed protect remote, virgin myocardium from subsequent sustained coronary artery occlusion in this canine model, and implies that preconditioning may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemic/reperfusion.
Journal ArticleDOI
Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
Hans Erik Bøtker,Rajesh K. Kharbanda,Michael Schmidt,Morten Bøttcher,Anne Kaltoft,Christian Juhl Terkelsen,Kim Munk,Niels Holmark Andersen,Troels Martin Hansen,Sven Trautner,Jens Flensted Lassen,Evald Høj Christiansen,Lars Romer Krusell,Steen Dalby Kristensen,Leif Thuesen,Søren Steen Nielsen,Michael Rehling,Henrik Toft Sørensen,Andrew N. Redington,Torsten Toftegaard Nielsen +19 more
TL;DR: The hypothesis that remote ischaemic conditioning during evolving ST-elevation myocardial infarction, and done before primary percutaneous coronary intervention, increasesMyocardial salvage, and has a favourable safety profile is tested.
Journal ArticleDOI
Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial
Derek J. Hausenloy,Peter K Mwamure,Vinod Venugopal,Joanne Harris,Matthew Barnard,Ernie Grundy,E Ashley,Sanjeev Vichare,Carmelo Di Salvo,Shyam Kolvekar,Martin Hayward,Bruce E. Keogh,Raymond J. MacAllister,Derek M. Yellon +13 more
TL;DR: It is shown that adult patients undergoing elective coronary artery bypass graft surgery at a single tertiary centre could benefit from remote ischaemic preconditioning, using transient upper limb ischaemia.
Journal ArticleDOI
Randomized controlled trial of the effects of remote ischemic preconditioning on children undergoing cardiac surgery: first clinical application in humans.
Michael Cheung,Rajesh K. Kharbanda,Igor E. Konstantinov,Mikiko Shimizu,Helena Frndova,Jia Li,Helen Holtby,Peter N. Cox,Jeffrey F. Smallhorn,Glen S. Van Arsdell,Andrew N. Redington +10 more
TL;DR: The myocardial protective effects of RIPC are demonstrated using a simple noninvasive technique of four 5-min cycles of lower limb ischemia and reperfusion using a blood pressure cuff in children undergoing repair of congenital heart defects.
Journal ArticleDOI
Cardioprotection: chances and challenges of its translation to the clinic
TL;DR: Conditioning protocols have been successfully used in patients undergoing elective coronary revascularisation and reperfusion after acute myocardial infarct, and pharmacological recruitment of cardioprotective signalling has also been used to reduce infarCT size, but so far without prognostic benefit.
Related Papers (5)
Remote ischaemic conditioning before hospital admission, as a complement to angioplasty, and effect on myocardial salvage in patients with acute myocardial infarction: a randomised trial
Hans Erik Bøtker,Rajesh K. Kharbanda,Michael Schmidt,Morten Bøttcher,Anne Kaltoft,Christian Juhl Terkelsen,Kim Munk,Niels Holmark Andersen,Troels Martin Hansen,Sven Trautner,Jens Flensted Lassen,Evald Høj Christiansen,Lars Romer Krusell,Steen Dalby Kristensen,Leif Thuesen,Søren Steen Nielsen,Michael Rehling,Henrik Toft Sørensen,Andrew N. Redington,Torsten Toftegaard Nielsen +19 more