Open AccessJournal Article
Cardioprotective effect of gemmotherapeutically treated Withania somnifera against chemically induced myocardial injury.
S. Hina,Khalil-ur-Rehman,Nazish Jahan,Mansoor Hameed,Z. Hassan,Zafar Iqbal Khan,Khawaja Shafique Ahmad,K. Mukhtar,Ehsan Elahi Valeem +8 more
TLDR
No significant change was observed in the activity of cardiac enzymes in baseline groups, and Protective actions of W. somnifera on heart have also been confirmed by gross pathology.Abstract:
The present study was designed to evaluate the preventive and curative cardioprotective potential of native and gemmotherapeutically treated on the basis of biochemical, histopathological and antioxidant parameters in the salbutamol (albuterol) induced myocardial necrosis in rabbits. Gemmotherapy is a newly emerging way of treatment and no work so far has been done on evaluation of curative cardioprotective potential of Withania somnifera. Rabbits were divided into eight main groups: Normal, Ischemia, WS Gemmo-baseline, WS Native-baseline, WS Gemmopreventive, WS Native-preventive, WS Gemmo-curative and WS Native-curative groups. Gemmo and native-baseline groups were treated with gemmo and native W. somnifera (50 mg/kg) for 20 days. Native and Gemmo-preventive groups were pre-treated with native and gemmotherapeutically treated W. somnifera at a dose 50 mg/kg for 3 weeks. On 20 th and 21 st day animals of all groups except normal and baseline groups were given Salbutamol (50mg/ kg), orally at an interval of 24 h. The Native-curative and Gemmo-curative groups were then treated with native and gemmotherapeutically treated W. somnifera at a dose 50 mg/ kg for 5 days, subsequent to the treatment with Salbutamol. Rabbits were subsequently sacrificed for gross pathological studies and hearts were removed for antioxidant assay. Administeration of Salbutamol significantly increased (p<0.05) the serum level of CK-MB, LDH, SGOT and SGPT in ischemia group as compared to Normal. However, pre- and post-treatment with Native and Gemmo extracts of W. somnifera significantly restored and reduced (p<0.05) the elevated serum levels of these cardiac markers. Also Native and Gemmo extracts of W. somnifera significantly increased (p<0.05) antioxidant enzymes; superoxide dismutase, catalase and glutathione peroxidase. No significant change was observed in the activity of cardiac enzymes in baseline groups. Protective actions of W. somnifera on heart have also been confirmed by gross pathology.read more
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Book ChapterDOI
Medicinal plants, human health and biodiversity: a broad review.
Tuhinadri Sen,Samir K. Samanta +1 more
TL;DR: Knowing is updated about the diverse therapeutic application of different plant products against various pharmacological targets including cancer, human brain, cardiovascular function, microbial infection, inflammation, pain, and many more are updated.
Journal ArticleDOI
Chemistry and pharmacology of withania somnifera: An update
TL;DR: The chemistry and pharmacological basis of W. somnifera in various human ailments is reviewed and efforts are ongoing to further explore other bioactive constituents of this plant.
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Antioxidant and anti-inflammatory medicinal plants have potential role in the treatment of cardiovascular disease: a review.
TL;DR: Reports have shown that bioactive compounds in plants with antioxidant, anti-inflammatory, ability to protect vascular endothelium, prevent lipid oxidation, and augment endogenous antioxidant system are cardioprotective, and Phenolics and flavonoids in medicinal plants have been widely reported to play these major roles.
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Curcumin in heart failure: A choice for complementary therapy?
Amin Saeidinia,Faeze Keihanian,Alexandra E. Butler,Ramin Khameneh Bagheri,Stephen L. Atkin,Amirhossein Sahebkar +5 more
TL;DR: The mechanisms by which curcumin may exert its effects in different models of heart failure are assessed and it is shown that it has promise as a complementary treatment in heart failure.
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Cardioprotective potential of gemmomodified extract of Terminalia arjuna against chemically induced myocardial injury in rabbits.
TL;DR: This dissertation aims to provide a history of web exceptionalism from 1989 to 2002, a period chosen in order to explore its roots as well as specific cases up to and including the year in which descriptions of “Web 2.0” began to circulate.
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Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study.
Michael G. L. Hertog,Daan Kromhout,Christ Aravanis,Henry Blackburn,Ratko Buzina,Flaminio Fidanza,Simona Giampaoli,Annemarie Jansen,Alessandro Menotti,Alessandro Menotti,Srecko Nedeljkovic,Maija Pekkarinen,Bozidar S. Simic,Hironori Toshima,Edith J. M. Feskens,Peter C. H. Hollman,Martijn B. Katan +16 more
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