Journal ArticleDOI
Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells
Wataru Ando,Kosuke Tateishi,David A. Hart,Daisuke Katakai,Yoshinari Tanaka,Ken Nakata,Jun Hashimoto,Hiromichi Fujie,Konsei Shino,Hideki Yoshikawa,Norimasa Nakamura +10 more
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TLDR
Implantation of a TEC into chondral defects initiated repair with a chondrogenic-like tissue, as well as secure biological integration to the adjacent cartilage, which revealed mechanical properties similar to those of normal porcine cartilage in static compression and friction tests.About:
This article is published in Biomaterials.The article was published on 2007-12-01. It has received 213 citations till now. The article focuses on the topics: Stem cell transplantation for articular cartilage repair & Cartilage.read more
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On the mechanisms of biocompatibility.
TL;DR: It is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that the material shall do no harm to those tissues, achieved through chemical and biological inertness.
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Unlike Bone, Cartilage Regeneration Remains Elusive
TL;DR: Bone-regeneration successes are used to highlight cartilage- Regeneration challenges: such as selecting appropriate cell sources and scaffolds, creating biomechanically suitable tissues, and integrating to native tissue.
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Safety and Complications Reporting Update on the Re-Implantation of Culture-Expanded Mesenchymal Stem Cells Using Autologous Platelet Lysate Technique
Christopher J. Centeno,John R. Schultz,Michelle Cheever,Brent Robinson,Michael D. Freeman,Wayne Marasco +5 more
TL;DR: Using both high field MRI tracking and general surveillance in 227 patients, no neoplastic complications were detected at any stem cell re-implantation site, consistent with other reports that also show no evidence of malignant transformation in vivo, following implantation of MSCs that were expanded in vitro for limited periods.
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Synovium-derived mesenchymal stem cells: a new cell source for musculoskeletal regeneration.
TL;DR: This review summarizes the latest advances in SMSC-related studies covering their specific isolation methodologies, biological insights, and practical applications in musculoskeletal therapeutics of which an emphasis is cast on engineered chondrogenesis.
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Mechanical Properties of Natural Cartilage and Tissue-Engineered Constructs
TL;DR: The mechanical behavior of native cartilage is discussed and different types of tensile, compressive, and shear tests with their limitations are surveyed.
References
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Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.
TL;DR: The existence of many new and encouraging biological approaches to cartilage repair justifies the future investment of time and money in this research area, particularly given the extremely high socio-economic importance of such therapeutic strategies in the prevention and treatment of these common joint diseases and traumas.
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Biomedical applications of collagen
TL;DR: In this paper, the authors reviewed biomedical applications of collagen including the collagen film, which was developed as a matrix system for evaluation of tissue calcification and for the embedding of a single cell suspension for tumorigenic study.
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Multipotent mesenchymal stem cells from adult human synovial membrane
TL;DR: It is demonstrated that human multipotent MSCs can be isolated from the SM of knee joints and have the ability to proliferate extensively in culture, and they maintain their multilineage differentiation potential in vitro, establishing their progenitor cell nature.
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Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source
TL;DR: There are significant differences in MSC properties according to tissue source, beyond donor and experimental variation, and Superiority of synovium as a potential source of MSCs for clinical applications was demonstrated.
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Human embryonic stem cells express an immunogenic nonhuman sialic acid
TL;DR: Levels of Neu5Gc on HESC and embryoid bodies dropped after culture in heat-inactivated anti-Neu5 Gc antibody–negative human serum, reducing binding of antibodies and complement from high-titer sera, while allowing maintenance of the undifferentiated state.