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Catalog of chromosome aberrations in cancer
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TLDR
This poster presents a probabilistic procedure to count the number of chromosomes in the nucleus using a simple “spatially aggregating” procedure called “spot-spot analysis”.Abstract:
Chromosome 1-22 Chromosome X Chromosome Y Homogeneously Staining Regions (HSR) Ring Chromosomes (R) Double Minute Chromosomes (DMIN).read more
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Book ChapterDOI
Karyotypic Evolution of Cells in Culture: A New Concept
TL;DR: A detailed description is presented of the author's original approach of cytogenetic analysis of cell lines provided for a principally new characteristic of the cell line: its generalized reconstructed karyotype (GRK), which is used as a criterion to evaluate authenticity, purity, and stability of cell Lines.
Journal ArticleDOI
Low number of DNA copy number changes in small lymphocytic lymphoma
TL;DR: The results indicate that trisomy 12 is one of the most frequent chromosomal aberrations in SLL, which may indicate that the genetic pathways in the development of SLL/CLL in patients presenting with enlarged lymph nodes (SLL) with or without leukemia are different from those in patients presented with leukemia (CLL) without enlarged lymph node.
Journal ArticleDOI
Cytogenetic analysis of a congenital fibrosarcoma
TL;DR: In this article, the authors performed cytogenetic analysis on a tumor with abnormal karyotype: 48,XY, +11, +20 and +20, and reported a specific pattern of trisomies that may prove diagnostic for this tumor.
Journal Article
Cell clonality in hypereosinophilic syndrome: what pathogenetic role?
Sara Galimberti,Elena Ciabatti,F Ottimo,Anna Maria Rossi,Luisa Trombi,Giovanni Carulli,Giulia Cervetti,Letizia Mattii,G Bianchi,Mario Petrini +9 more
TL;DR: It is suggested that a real distinction between m- and l-HES is not wholly convincing and that clonal T-cell expansion could not be the "primum movens" but an epiphenomenon in HES.
Journal ArticleDOI
Translocation(8;20;21)(q22;q13;q22) in acute myeloblastic leukemia with maturation : A variant form of t(8;21)
Kit-Fai Wong,YL Kwong,C.C So +2 more
TL;DR: Molecular analysis of the marrow mononuclear cells by reverse transcription-polymerase chain reaction with nested AML1 and ETO primers showed amplification of the AML/ETO fusion transcript, thus confirming that the chromosomal aberration was in fact a masked t(8;21), i.e., variant t( 8;20;21)(q22;q13;q22).