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Catalog of chromosome aberrations in cancer
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TLDR
This poster presents a probabilistic procedure to count the number of chromosomes in the nucleus using a simple “spatially aggregating” procedure called “spot-spot analysis”.Abstract:
Chromosome 1-22 Chromosome X Chromosome Y Homogeneously Staining Regions (HSR) Ring Chromosomes (R) Double Minute Chromosomes (DMIN).read more
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Journal ArticleDOI
Chromosome abnormalities in benign prostatic hyperplasia
TL;DR: This data indicates that trisomy 7 may be unrelated to the origin of benign prostate hyperplasia, in which the only and not very specific change seems to be the loss of the Y chromosome.
Journal ArticleDOI
Genetic characterization of human c-rel sequences.
TL;DR: A human genomic-DNA segment is isolated that is homologous to a portion of v-rel, the transforming gene of reticuloendotheliosis virus (strain T) and localized to human chromosome 2 by screening a panel of rodent X human somatic-cell hybrids with the newly described human rel segment.
Journal ArticleDOI
Analysis of hematologic diseases using conventional karyotyping, fluorescence in situ hybridization (FISH), and comparative genomic hybridization (CGH)
TL;DR: Although CGH was not able to detect all aberrations, it gave important additional information for the correct localization of the aberration found in CC, and it was most helpful in samples not processed successfully in CC.
Journal ArticleDOI
Near-haploidy in two malignant fibrous histiocytomas
TL;DR: Cytogenetic analysis of two malignant fibrous histiocytomas revealed near-haploid clones in both tumors, suggesting that this otherwise rare phenomenon in neoplasia may be relatively common in MFH.
Book ChapterDOI
Genomic Stability and Instability: A Working Paradigm
Keith C. Cheng,Lawrence A. Loeb +1 more
TL;DR: The challenging task of accurate DNA replication and distribution must be accomplished while the cell is under constant attack by forces that damage DNA.