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Catalog of chromosome aberrations in cancer
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TLDR
This poster presents a probabilistic procedure to count the number of chromosomes in the nucleus using a simple “spatially aggregating” procedure called “spot-spot analysis”.Abstract:
Chromosome 1-22 Chromosome X Chromosome Y Homogeneously Staining Regions (HSR) Ring Chromosomes (R) Double Minute Chromosomes (DMIN).read more
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Journal ArticleDOI
The class II tumor-suppressor gene RARRES3 is expressed in B cell lymphocytic leukemias and down-regulated with disease progression.
Benito Casanova,M T de la Fuente,Mercedes Garcia-Gila,Laura Sanz,Augusto Silva,José A. García-Marco,Angeles García-Pardo +6 more
TL;DR: A correlation between RAR RES3 down-regulation and B-CLL progression is reported and indicates that RARRES3 may play a role in B- CLL progression.
Journal ArticleDOI
Chromosome aberrations, spontaneous SCE, and growth kinetics in PHA-stimulated lymphocytes of five cases with Sézary syndrome
Janusz Limon,Bogusław Nedoszytko,Izabela Brozek,Andrzej Hellmann,Stanislaw Zajaczek,Jan Lubinski,Krzysztof Mrózek +6 more
TL;DR: Cell cycle kinetics analysis revealed that the cell cycle time in the malignant cells was significantly longer than in lymphocytes of normal individuals, and sister chromatid exchange frequencies were significantly higher in comparison to the normal control.
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Genetic markers as prognostic indicators in breast cancer.
Sandra R. Wolman,Robert J. Pauley,Anwar N. Mohamed,Peter J. Dawson,Daniel W. Visscher,Fazlul H. Sarkar +5 more
TL;DR: Currently, to the authors' knowledge, none has shown uniform changes by mutation, loss, or overexpression in all breast cancers, although a remarkable number of loci are altered to some extent.
Journal ArticleDOI
Complex variant 15;17 translocations in acute promyelocytic leukemia. A case report and review of three-way translocations.
TL;DR: A novel three-way translocation in APL involving chromosomes 15, 17, and X in the form of t(X;17;15)(q13;q12;q21) shows clinical and morphologic findings typical of APL, and a complete remission was attained with a course of conventional chemotherapy.
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Involvement of chromosomes 3 and 5 in renal cell carcinoma.
Paola Dal Cin,Frederick P. Li,George R. Prout,Robert P. Huben,Janusz Limon,Angeliki Ferti-Passantonopoulou,Jerome P. Richie,Avery A. Sandberg +7 more
TL;DR: The breakpoints on chromosome 3 in seven specimens clustered in region 3p11-3p24.2 confirmed its importance in the genesis of renal cell carcinoma, and an i(5p) and involvement of band 5q21 were other frequent structural chromosome changes.