Open AccessBook
Catalog of chromosome aberrations in cancer
Reads0
Chats0
TLDR
This poster presents a probabilistic procedure to count the number of chromosomes in the nucleus using a simple “spatially aggregating” procedure called “spot-spot analysis”.Abstract:
Chromosome 1-22 Chromosome X Chromosome Y Homogeneously Staining Regions (HSR) Ring Chromosomes (R) Double Minute Chromosomes (DMIN).read more
Citations
More filters
Journal ArticleDOI
TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia
T. W. Mclean,S. Ringold,Donna Neuberg,Kimberly Stegmaier,Ramana Tantravahi,Jerome Ritz,H. P. Koeffler,S. Takeuchi,J. W. G. Janssen,T. Seriu,C. R. Bartram,Stephen E. Sallan,D G Gilliland,Todd R. Golub +13 more
TL;DR: Co-immunoprecipitation experiments demonstrated that TEL/AML-1 formed homodimers in vitro, and heterodimerized with the normal TEL protein when the two proteins were expressed together.
Journal ArticleDOI
Molecular cytogenetic analysis of Spitz nevi shows clear differences to melanoma
TL;DR: Clear differences in the location and frequencies of chromosomal aberrations in Spitz nevi and primary cutaneous melanomas could represent a basis for developing adjunctive techniques for refining accuracy in the difficult differential diagnosis of spitzoid melanocytic neoplasms.
Journal ArticleDOI
Determining centromere identity: cyclical stories and forking paths
TL;DR: Recent studies that have elucidated the organization and functions of centromeric chromatin are reviewed, and present-day models for how centromere identity and propagation are determined are evaluated.
Journal Article
Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases.
Cristina R. Antonescu,Sylvia J. Tschernyavsky,Ramona Decuseara,Denis H. Y. Leung,James M. Woodruff,Murray F. Brennan,Julia A. Bridge,James R. Neff,John R. Goldblum,Marc Ladanyi +9 more
TL;DR: The molecular variability of TLS-CHOP fusion transcript structure does not appear to have a significant impact on clinical outcome in MLS, and high histological grade, presence of necrosis, and P53 overexpression are predictors of unfavorable outcome in localized MLS.
Journal Article
Karyotypic Complexity of the NCI-60 Drug-Screening Panel
Anna V. Roschke,Giovanni Tonon,Kristen Gehlhaus,Nicolas McTyre,Kimberly J. Bussey,Samir Lababidi,Dominic A. Scudiero,John N. Weinstein,Ilan R. Kirsch,Ilan R. Kirsch +9 more
TL;DR: This dataset offers insights into the causes and consequences of the destabilizing events and chromosomal instability that may occur during tumor development and progression and provides a foundation for investigating associations between structural genome anatomy and cancer molecular markers and targets, gene expression, gene dosage, and resistance or sensitivity to tens of thousands of molecular compounds.