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Catalog of chromosome aberrations in cancer
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TLDR
This poster presents a probabilistic procedure to count the number of chromosomes in the nucleus using a simple “spatially aggregating” procedure called “spot-spot analysis”.Abstract:
Chromosome 1-22 Chromosome X Chromosome Y Homogeneously Staining Regions (HSR) Ring Chromosomes (R) Double Minute Chromosomes (DMIN).read more
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Trisomy 8 as a nonrandom secondary change in myxoid liposarcoma
TL;DR: In all 5 tumors a t(12:16)(q13:p11), characteristic of the myxoid form of liposarcoma, was observed, and trisomy 8 was present in two tumors as the only additional change and in a third in addition to other abnormalities.
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A cytokine receptor gene cluster in the X-Y pseudoautosomal region?
Eric J. Kremer,Elizabeth Baker,Richard J D'Andrea,Rima Slim,H.A. Phillips,PA Moretti,Angel F. Lopez,C Petit,MA Vadas,Grant R. Sutherland +9 more
TL;DR: Using long-range restriction mapping, it is found that IL3RA maps to the same 190-kb restriction fragment as CSF2RA, suggesting that a cytokine receptor gene cluster may reside in the PAR.
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Single-particle irradiation of mammalian cells at the radiological research accelerator facility: induction of chromosomal changes☆
TL;DR: A dedicated beam line (microbeam) is developed on a 4.2 MV Van de Graaff accelerator such that individual particles will vertically traverse individual living mammalian cells positioned by a microscope-based imaging system under computer control, allowing critical evaluations of the potential of individual high LET charged particles to initiate change.
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Genomic instability and prognosis in breast carcinomas.
Ulrike Kronenwett,Alexander Ploner,Anders Zetterberg,Jonas Bergh,Per Hall,Gert Auer,Yudi Pawitan +6 more
TL;DR: Objective classification of breast adenocarcinomas into stable and unstable subtypes is a useful prognostic indicator independent of established clinical factors.
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Characterization of 20q deletions in patients with myeloproliferative disorders or myelodysplastic syndromes
TL;DR: The structure of the del(20q) in 30 patients and two cell lines was analyzed and six small deletions were identified, defining a minimal deleted region extending from 20q11.2-20q13.1.