Journal ArticleDOI
Cdk5 Promotes Mitochondrial Fission via Drp1 Phosphorylation at S616 in Chronic Ethanol Exposure–Induced Cognitive Impairment
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TLDR
It is demonstrated that inhibition of aberrant Cdk5 activation attenuates hippocampal neuron injury and cognitive deficits induced by chronic exposure to ethanol through Drp1-mediated mitochondrial fission and mitochondrial dysfunction.About:
This article is published in Molecular Neurobiology.The article was published on 2022-09-09. It has received 4 citations till now. The article focuses on the topics: Medicine & Mitochondrial fission.read more
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CB2R activation ameliorates late adolescent chronic alcohol exposure-induced anxiety-like behaviors during withdrawal by preventing morphological changes and suppressing NLRP3 inflammasome activation in prefrontal cortex microglia in mice
TL;DR: In this paper , the role of CB2R activation in ameliorating late adolescent CAE-induced anxiety-like behaviors and microglial activation in C57BL/6J mice was investigated.
Journal ArticleDOI
Evaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats
TL;DR: In this article , the authors used the standard two-bottle preference choice test to evaluate the effect of alcohol consumption on hippocampal neurotoxicity in adult Sprague-Dawley rats.
Journal ArticleDOI
Rutaecarpine Mitigates Cognitive Impairment by Balancing Mitochondrial Function Through Activation of the AMPK/PGC1α Pathway.
Min Gong,Jianping Jia +1 more
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ERK1/2 regulates Epileptic Seizures by modulating the DRP1 mediated Mitochondrial Dynamic
TL;DR: In this paper , LiCl-Pilocarpine was injected intraperitoneally to establish a status epilepticus (SE) rat for this study, and the number of seizures and the latency of the first seizure were then monitored.
References
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Journal ArticleDOI
Analysis of relative gene expression data using real-time quantitative pcr and the 2(-delta delta c(t)) method
TL;DR: The 2-Delta Delta C(T) method as mentioned in this paper was proposed to analyze the relative changes in gene expression from real-time quantitative PCR experiments, and it has been shown to be useful in the analysis of realtime, quantitative PCR data.
Journal ArticleDOI
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.
Caroline E. Shamu,Peter Walter +1 more
TL;DR: Molecular genetic and biochemical studies described here suggest that, as in the case of growth factor receptors of higher eukaryotic cells, Ire1p oligomerizes in response to the accumulation of unfolded proteins in the ER and is phosphorylated in trans by otherIre1p molecules as a result of oligomerization.
Journal ArticleDOI
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin,M. Flint Beal +1 more
TL;DR: Treatments targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria hold great promise in ageing-related neurodegenerative diseases.
Journal ArticleDOI
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission.
Gill Livingston,Gill Livingston,Jonathan Huntley,Andrew Sommerlad,Andrew Sommerlad,David Ames,Clive Ballard,Sube Banerjee,Carol Brayne,Alistair Burns,Jiska Cohen-Mansfield,Claudia Cooper,Sergi G. Costafreda,Amit Dias,Nick C. Fox,Laura N. Gitlin,Robert Howard,Helen C. Kales,Mika Kivimäki,Eric B. Larson,Adesola Ogunniyi,Vasiliki Orgeta,Karen Ritchie,Kenneth Rockwood,Elizabeth L Sampson,Quincy M. Samus,Lon S. Schneider,Geir Selbæk,Linda Teri,Naaheed Mukadam +29 more
TL;DR: Author(s): Livingston, Gill; Huntley, Jonathan; Sommerlad, Andrew ; Sommer Glad, Andrew; Ames, David; Ballard, Clive; Banerjee, Sube; Brayne, Carol; Burns, Alistair; Cohen-Mansfield, Jiska; Cooper, Claudia; Costafreda, Sergi G; Dias, Amit; Fox, Nick; Gitlin, Laura N; Howard, Robert; Kales, Helen C;
Journal ArticleDOI
Morris water maze: procedures for assessing spatial and related forms of learning and memory
TL;DR: The Morris water maze has proven to be a robust and reliable test that is strongly correlated with hippocampal synaptic plasticity and NMDA receptor function and trial-dependent, latent and discrimination learning can be assessed using modifications of the basic protocol.