Central obesity and hypertension: The role of plasma endothelin
Gaspare Parrinello,Rosario Scaglione,Antonio Pinto,Salvatore Corrao,Mariagrazia Cecala,Grazia Di Silvestre,P Amato,Anna Licata,Giuseppe Licata +8 more
TLDR
The data suggest that obesity-associated hypertension is characterized by an endothelial dysfunction that may contribute to the higher cardiovascular risk detectable in these patients.About:
This article is published in American Journal of Hypertension.The article was published on 1995-04-01 and is currently open access. It has received 69 citations till now. The article focuses on the topics: Ambulatory blood pressure & Endothelins.read more
Citations
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Obesity, sleep apnea, and hypertension.
TL;DR: The coexistence of OSA and obesity may have more widespread implications for cardiovascular control and dysfunction in obese individuals and may contribute to some of the clustering of abnormalities broadly defined as the metabolic syndrome.
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Endothelin: 20 years from discovery to therapy.
TL;DR: Twenty years after the discovery of endothelin, its inhibitors have finally arrived in the clinical arena and are now providing us with new options to treat disease and prolong the lives of patients.
Journal ArticleDOI
Overweight and Obese Humans Demonstrate Increased Vascular Endothelial NAD(P)H Oxidase-p47phox Expression and Evidence of Endothelial Oxidative Stress
Annemarie Silver,Stacy D. Beske,Demetra D. Christou,Anthony J. Donato,Kerrie L. Moreau,Kerrie L. Moreau,Iratxe Eskurza,Phillip E. Gates,Douglas R. Seals,Douglas R. Seals +9 more
TL;DR: Compared with their normal-weight peers, overweight and obese adults demonstrate increased vascular endothelial expression of NAD(P)H oxidase-p47phox and evidence of endothelial oxidative stress, with selective compensatory upregulation of antioxidant enzymes and Ser1177-phosphorylated endothelial nitric oxide synthase.
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The Lys198Asn polymorphism in the endothelin-1 gene is associated with blood pressure in overweight people.
Laurence Tiret,Odette Poirier,Vincent Hallet,Theresa McDonagh,Caroline Morrison,John J.V. McMurray,Henry J. Dargie,Dominique Arveiler,Jean-Bernard Ruidavets,Gérald Luc,Alun Evans,François Cambien +11 more
TL;DR: Results from 2 independent studies suggest that the ET1/C198 polymorphism is associated with blood pressure levels in overweight people.
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Role of endothelin in human hypertension.
TL;DR: Targeting the endothelin system may have important therapeutic potential in the treatment of hypertension, particularly by contributing to the prevention of target organ damage and the management of cardiovascular disease.
References
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A novel potent vasoconstrictor peptide produced by vascular endothelial cells.
Masashi Yanagisawa,Hiroki Kurihara,Hiroki Kurihara,Sadao Kimura,Yoko Tomobe,Mieko Kobayashi,Youji Mitsui,Yoshio Yazaki,Katsutoshi Goto,Tomoh Masaki +9 more
TL;DR: Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
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Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.
TL;DR: It is concluded that insulin resistance and/or hyperinsulinemia are present in the majority of hypertensives, constitute a common pathophysiologic feature of obesity, glucose intolerance, and hypertension, possibly explaining their ubiquitous association, and may be linked to the increased peripheral vascular resistance of hypertension, which is putatively related to elevated intracellular sodium concentration.
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The Effect of Weight Loss on the Sensitivity of Blood Pressure to Sodium in Obese Adolescents
Albert P. Rocchini,Jane Key,Diane Bondie,Robin Chico,Catherine Moorehead,Victor L. Katch,Monica M. Martin +6 more
TL;DR: The hypothesis that the blood pressure of obese adolescents is sensitive to dietary sodium intake is supported and that this sensitivity may be due to the combined effects of the hyperinsulinemia, hyperaldosteronism, and increased activity of the sympathetic nervous system that are characteristic of obesity.
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Impaired left ventricular diastolic filling in patients with coronary artery disease: assessment with radionuclide angiography.
Robert O. Bonow,Stephen L. Bacharach,Michael V. Green,Kenneth M. Kent,Douglas R. Rosing,Lewis C. Lipson,Martin B. Leon,S E Epstein +7 more
TL;DR: LV diastolic filling, evaluated noninvasively by radionuclide angiography, is abnormal in a high percentage of patients with CAD at rest independent of LV systolic function or previous myocardial infarction.
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Overweight and Hypertension A Review
TL;DR: Although it is not precisely known to what extent weight reduction alone may be effective in controlling or preventing the lesser degrees of hypertension, the control of obesity should be an intrinsic part of any therapeutic or preventive antihypertensive regimen.