Journal ArticleDOI
Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids.
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TLDR
The presented carrier of colloidal lipid particles with improved payloads and enhanced storage stability was investigated and adds additional benefits to the well-known opportunities of conventional SLN and is suited for topical use.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2000-04-20. It has received 542 citations till now. The article focuses on the topics: Solid lipid nanoparticle & Drug carrier.read more
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.
Journal ArticleDOI
Solid lipid nanoparticles for parenteral drug delivery.
TL;DR: The biological activity of parenterally applied SLN and biopharmaceutical aspects such as pharmacokinetic profiles as well as toxicity aspects are reviewed.
Journal ArticleDOI
Structural design principles for delivery of bioactive components in nutraceuticals and functional foods.
TL;DR: This review begins by discussing some of the major nutraceutical and functional food components that need to be delivered and highlights the main limitations to their current utilization within the food industry.
Journal ArticleDOI
Lipid-based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
Anu Puri,Kristin H. Loomis,Brandon Smith,Jae-Ho Lee,Amichai Yavlovich,Eliahu Heldman,Robert Blumenthal +6 more
TL;DR: This review will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery, including a review of current activities in the field of liposomes, and challenging issues of targeting and triggering will be discussed in detail.
Journal ArticleDOI
Physico-chemical stability of colloidal lipid particles.
TL;DR: This review focuses on the physico-chemical stability of dispersions in the nanometer range where the lipids are the main or the only components and on the destabilization mechanisms, techniques used to detect this destabilization and the inductors of the destabilizations.
References
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Book
Foundations of Colloid Science
TL;DR: The structure of concentrated dispersions thin films Emulsions Microemulsions Rheology of colloidal dispersions and their properties are described in detail in this paper, with a focus on statistical mechanics of fluids.
Journal ArticleDOI
Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential
TL;DR: Improved stability and loading capacities were found for amorphous lipid nanoparticles which present the characteristic signals of supercooled melts in high resolution 1 H-NMR, and significant differences between monoacid triglycerides and complex lipids were found.
Book
Crystallization and polymorphism of fats and fatty acids
Nissim Garti,Kiyotaka Sato +1 more
TL;DR: In this paper, the physical and chemical characteristics of fats and fatty acids, and two approaches the microscopic analysis of polymorphic structures, and macroscopic technical control of production are discussed.
Journal ArticleDOI
Crystallization tendency and polymorphic transitions in triglyceride nanoparticles
TL;DR: The ability of tristearin, tripalmitin, trimyristin and trilaurin to form solid lipid nanoparticles after melt-homogenization is investigated by DSC and X-ray diffraction.
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Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more