Characterising long COVID: a living systematic review.
Melina Michelen,Melina Michelen,Lakshmi Manoharan,Natalie Elkheir,Vincent Cheng,Andrew Dagens,Claire E. Hastie,Margaret E O’Hara,Jake Suett,Dania T Dahmash,Polina Bugaeva,Ishmeala Rigby,Daniel Munblit,Daniel Munblit,Eli Harriss,Amanda Burls,Carole Foote,Janet T Scott,Gail Carson,Piero Olliaro,Louise Sigfrid,Charitini Stavropoulou +21 more
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TLDR
In this article, a living systematic review was conducted to synthesize evidence on Long Covid characteristics, to inform clinical management, rehabilitation, and interventional studies to improve long term outcomes.Abstract:
Background: While it is now apparent clinical sequelae (often called Long Covid) may persist after acute Covid-19, their nature, frequency, and aetiology are poorly characterised. This study aims to regularly synthesise evidence on Long Covid characteristics, to inform clinical management, rehabilitation, and interventional studies to improve long term outcomes.
Methods: A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research Database on Covid-19, LitCOVID, and Google Scholar were searched up to 17th March 2021. Published studies including at least 100 people with confirmed or clinically suspected Covid-19 at 12 weeks or more post-onset were included. Results were analysed using descriptive statistics and meta-analyses to estimate prevalence with 95% confidence intervals (CIs).
Results: Thirty-nine studies were included: 32 cohort, six cross-sectional, and one case-control. Most showed high or moderate risk of bias. None were set in low-income countries, limited studies included children. Studies reported on 10,951 people (48% female) in 12 countries. Most followed-up post hospital discharge (78%, 8520/10951). The longest mean follow-up was 221.7 (SD: 10.9) days post Covid-19 onset. An extensive range of symptoms with wide prevalence was reported, most commonly weakness (41%; 95% CI 25% to 59%), malaise (33%; 95% CI 15% to 57%), fatigue (31%; 95% CI 24% to 39%), concentration impairment (26%; 95% CI 21% to 32%), and breathlessness (25%; 95% CI 18% to 34%). Other frequent symptoms included musculoskeletal, neurological, and psychological. 37% (95% CI 18% to 60%) of people reported reduced quality of life.
Conclusion: Long Covid is a complex condition with heterogeneous symptoms. The nature of the studies precludes a precise case definition or evaluation of risk factors. There is an urgent need for prospective, robust, standardised controlled studies into aetiology, risk factors, and biomarkers to characterise Long Covid in different at-risk populations and settings.
Systematic review registration: The protocol was prospectively registered on the PROSPERO database (CRD42020211131).read more
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Musculoskeletal complications in long COVID-19: A systematic review
TL;DR: In this article , the authors performed a systematic review to determine the musculoskeletal complications in long Coronavirus disease 2019 (COVID-19) infection, and found that fatigue was the most common complication along with myalgia and arthralgia.
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16 Months Follow Up of Patients’ Behavior and Mild COVID-19 Patterns in a Large Cohort of Cancer Patients During the Pandemic
Nawale Hajjaji,Kathleen Lepoutre,Sarra Lakhdar,Stéphanie Becourt,Charlotte Bellier,Emilie Kaczmarek,Antonin Broyelle,Sandrine Giscard,Eric Lartigau +8 more
TL;DR: A longitudinal online survey was conducted for 16 months during the pandemic in a large cohort of cancer patients from a French COVID-19 hot spot and showed a high prevalence of long-lasting symptoms in cancer patients with mild CO VID-19 infection and inadequate behavior toward the disease and prevention measures among patients.
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STIMULATE-ICP: A pragmatic, multi-centre, cluster randomised trial of an integrated care pathway with a nested, Phase III, open label, adaptive platform randomised drug trial in individuals with Long COVID: a structured protocol
TL;DR: In this paper , the authors present a pragmatic, multi-centre, cluster-randomised clinical trial of two components of an integrated care pathway (Coverscan ™, a multi-organ MRI, and Living with COVID Recovery ™ , a digitally enabled rehabilitation platform) with a nested, Phase III, open label, platform randomised drug trial in individuals with long COVID.
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Long-term COVID symptoms, work ability and fitness to work in healthcare workers hospitalized for sars-CoV-2 infection
Marco Mendola,Marco Leoni,Ylenia Cozzi,Andrea Manzari,Fabio Tonelli,Francesca Metruccio,Luca Tosti,Vera Battini,Isabella Cucchi,Maria Cristina Costa,Paolo Carrer +10 more
TL;DR: Post-COVID-19 symptoms can persist for a long time and could impact WA and fitness-to-work of HCW, so adequate health surveillance protocols should guarantee the health protection of HCWs with persistent disorders after COVID- 19.
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Does pre-infection stress increase the risk of long COVID? Longitudinal associations between adversity worries and experiences in the month prior to COVID-19 infection and the development of long COVID and specific long COVID symptoms
Elena F. Paul,D. Fancourt +1 more
TL;DR: For example, this paper found that the number of worries about adversity experiences was associated with increased odds of having difficulty with mobility, cognition, and self-care during COVID-19 infection.
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