Characterising long COVID: a living systematic review.
Melina Michelen,Melina Michelen,Lakshmi Manoharan,Natalie Elkheir,Vincent Cheng,Andrew Dagens,Claire E. Hastie,Margaret E O’Hara,Jake Suett,Dania T Dahmash,Polina Bugaeva,Ishmeala Rigby,Daniel Munblit,Daniel Munblit,Eli Harriss,Amanda Burls,Carole Foote,Janet T Scott,Gail Carson,Piero Olliaro,Louise Sigfrid,Charitini Stavropoulou +21 more
Reads0
Chats0
TLDR
In this article, a living systematic review was conducted to synthesize evidence on Long Covid characteristics, to inform clinical management, rehabilitation, and interventional studies to improve long term outcomes.Abstract:
Background: While it is now apparent clinical sequelae (often called Long Covid) may persist after acute Covid-19, their nature, frequency, and aetiology are poorly characterised. This study aims to regularly synthesise evidence on Long Covid characteristics, to inform clinical management, rehabilitation, and interventional studies to improve long term outcomes.
Methods: A living systematic review. Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research Database on Covid-19, LitCOVID, and Google Scholar were searched up to 17th March 2021. Published studies including at least 100 people with confirmed or clinically suspected Covid-19 at 12 weeks or more post-onset were included. Results were analysed using descriptive statistics and meta-analyses to estimate prevalence with 95% confidence intervals (CIs).
Results: Thirty-nine studies were included: 32 cohort, six cross-sectional, and one case-control. Most showed high or moderate risk of bias. None were set in low-income countries, limited studies included children. Studies reported on 10,951 people (48% female) in 12 countries. Most followed-up post hospital discharge (78%, 8520/10951). The longest mean follow-up was 221.7 (SD: 10.9) days post Covid-19 onset. An extensive range of symptoms with wide prevalence was reported, most commonly weakness (41%; 95% CI 25% to 59%), malaise (33%; 95% CI 15% to 57%), fatigue (31%; 95% CI 24% to 39%), concentration impairment (26%; 95% CI 21% to 32%), and breathlessness (25%; 95% CI 18% to 34%). Other frequent symptoms included musculoskeletal, neurological, and psychological. 37% (95% CI 18% to 60%) of people reported reduced quality of life.
Conclusion: Long Covid is a complex condition with heterogeneous symptoms. The nature of the studies precludes a precise case definition or evaluation of risk factors. There is an urgent need for prospective, robust, standardised controlled studies into aetiology, risk factors, and biomarkers to characterise Long Covid in different at-risk populations and settings.
Systematic review registration: The protocol was prospectively registered on the PROSPERO database (CRD42020211131).read more
Citations
More filters
Posted ContentDOI
Mobile Primary Healthcare for post-COVID Patients in Rural Areas: a Proof-of-Concept Study
TL;DR: In this article , the authors investigated physical fitness, fatigue, depression, cognitive dysfunction and dyspnea in patients with post-COVID syndrome in a mobile interdisciplinary post-coVID outpatient clinic.
Journal ArticleDOI
Postacute Sequelae of SARS-CoV-2: Musculoskeletal Conditions and Pain
TL;DR: In this article , the authors explore what is currently known about post-acute sequelae of COVID-19 (PASC) and its pathophysiology as well as strategies for diagnosis and management.
Journal ArticleDOI
Preparing for pandemics: a systematic review of pandemic influenza clinical management guidelines
Ishmeala Rigby,Melina Michelen,Vincent Cheng,Andrew Dagens,Dania T Dahmash,Samuel Lipworth,Eli Harriss,Erhui Cai,Valeria Balan,Alexandra Oti,Reena Joseph,Helen Groves,Peter Hart,Shevin T. Jacob,Lucille Blumberg,Peter Horby,Louise Sigfrid +16 more
TL;DR: In this article , a systematic review aims to evaluate the availability, inclusivity, and quality of pandemic influenza CMGs to identify gaps that can be addressed to strengthen pandemic preparedness in this area.
Posted ContentDOI
Excess burden of respiratory and abdominal conditions following COVID-19 infections during the ancestral and Delta variant periods in the United States: An EHR-based cohort study from the RECOVER Program
Jay K. Varma,Chengxi Zang,Thomas W Carton,Jason P. Block,Dhruv Khullar,Yongkang Zhang,Mark G. Weiner,Russell L. Rothman,Edward J. Schenck,Zhenxing Xu,Kristin Lyman,Jiang Bian,Jie Xu,Elizabeth Shenkman,Christine Maughan,Leah Castro-Baucom,Lisa Oâ Brien,Fei Wang,Rainu Kaushal +18 more
TL;DR: In this paper , the frequency and characteristics of post-acute sequelae of SARS-CoV-2 infection (PASC) may vary by SARS CoV2 variant.
Journal ArticleDOI
Dyspnoea in COVID-19 recovery beyond the intensive care unit: the potential impact of inspiratory muscle weakness
TL;DR: The impact of breathlessness on the disability associated with long COVID is less well understood as mentioned in this paper , however, the potential contribution of breathlessness to this disability deserves to be more deeply explored, not least because it could be treatable.
References
More filters
Book
ggplot2: Elegant Graphics for Data Analysis
TL;DR: This book describes ggplot2, a new data visualization package for R that uses the insights from Leland Wilkisons Grammar of Graphics to create a powerful and flexible system for creating data graphics.
Journal ArticleDOI
Quantifying heterogeneity in a meta‐analysis
TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
Matthew J. Page,Joanne E. McKenzie,Patrick M.M. Bossuyt,Isabelle Boutron,Tammy Hoffmann,Cynthia D. Mulrow,Larissa Shamseer,Jennifer Tetzlaff,Elie A. Akl,Sue E. Brennan,Roger Chou,Julie Glanville,Jeremy M. Grimshaw,Asbjørn Hróbjartsson,Manoj M. Lalu,Tianjing Li,Elizabeth Loder,Evan Mayo-Wilson,Steve McDonald,Luke A McGuinness,Lesley A. Stewart,James Thomas,Andrea C. Tricco,Vivian Welch,Penny Whiting,David Moher +25 more
TL;DR: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement as discussed by the authors was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found.
Journal ArticleDOI
Rayyan-a web and mobile app for systematic reviews.
TL;DR: The strongest features of the app, identified and reported in user feedback, were its ability to help in screening and collaboration as well as the time savings it affords to users.
Related Papers (5)
Characterising long-term covid-19: a rapid living systematic review
Melina Michelen,Melina Michelen,Vincent Cheng,Lakshmi Manoharan,Natalie Elkheir,Natalie Elkheir,Drew Dagens,Claire E. Hastie,Margaret E O’Hara,Jake Suett,Dania T Dahmash,Polina Bugaeva,Ishmeala Rigby,Daniel Munblit,Daniel Munblit,Eli Harriss,Amanda Burls,Carol Foote,Janet T Scott,Gail Carson,Piero Olliaro,Louise Sigfrid,Charitini Stavropoulou +22 more
Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study
I.M. Osmanov,Ekaterina Spiridonova,Polina Bobkova,Aysylu Gamirova,Anastasia Shikhaleva,Margarita Andreeva,Oleg Blyuss,Oleg Blyuss,Yasmin El-Taravi,Audrey DunnGalvin,Audrey DunnGalvin,Pasquale Comberiati,Diego Peroni,Christian Apfelbacher,Jon Genuneit,Lyudmila Mazankova,Alexandra Miroshina,Evgeniya Chistyakova,Elmira Samitova,Svetlana Borzakova,Elena Bondarenko,Anatoliy A Korsunskiy,Irina Konova,Sarah Wulf Hanson,Gail Carson,Louise Sigfrid,Janet T Scott,Matthew Greenhawt,Elizabeth Whittaker,Elena Garralda,Olivia Swann,Danilo Buonsenso,Dasha Nicholls,Frances Simpson,Christina J Jones,Malcolm G Semple,Malcolm G Semple,John O. Warner,Theo Vos,Piero Olliaro,Daniel Munblit,Daniel Munblit +41 more