Characteristics associated with hospitalisation for COVID-19 in people with rheumatic disease: data from the COVID-19 Global Rheumatology Alliance physician-reported registry.
Milena A. Gianfrancesco,Kimme L. Hyrich,Sarah Al-Adely,Loreto Carmona,Maria I. Danila,Maria I. Danila,Laure Gossec,Zara Izadi,Lindsay Jacobsohn,Patricia P. Katz,Saskia Lawson-Tovey,Elsa F Mateus,Stephanie Rush,Gabriela Schmajuk,Julia F. Simard,Anja Strangfeld,Laura Trupin,Katherine D Wysham,Suleman Bhana,Wendy Costello,Rebecca Grainger,Jonathan S. Hausmann,Jonathan S. Hausmann,Jean W. Liew,Emily Sirotich,Paul Sufka,Zachary S. Wallace,Jinoos Yazdany,Pedro Machado,Philip Robinson,Philip Robinson +30 more
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TLDR
It is found that glucocorticoid exposure of ≥10 mg/day is associated with a higher odds of hospitalisation and anti-TNF with a decreased odds ofospitalisation in patients with rheumatic disease.Abstract:
Objectives COVID-19 outcomes in people with rheumatic diseases remain poorly understood. The aim was to examine demographic and clinical factors associated with COVID-19 hospitalisation status in people with rheumatic disease. Methods Case series of individuals with rheumatic disease and COVID-19 from the COVID-19 Global Rheumatology Alliance registry: 24 March 2020 to 20 April 2020. Multivariable logistic regression was used to estimate ORs and 95% CIs of hospitalisation. Age, sex, smoking status, rheumatic disease diagnosis, comorbidities and rheumatic disease medications taken immediately prior to infection were analysed. Results A total of 600 cases from 40 countries were included. Nearly half of the cases were hospitalised (277, 46%) and 55 (9%) died. In multivariable-adjusted models, prednisone dose ≥10 mg/day was associated with higher odds of hospitalisation (OR 2.05, 95% CI 1.06 to 3.96). Use of conventional disease-modifying antirheumatic drug (DMARD) alone or in combination with biologics/Janus Kinase inhibitors was not associated with hospitalisation (OR 1.23, 95% CI 0.70 to 2.17 and OR 0.74, 95% CI 0.37 to 1.46, respectively). Non-steroidal anti-inflammatory drug (NSAID) use was not associated with hospitalisation status (OR 0.64, 95% CI 0.39 to 1.06). Tumour necrosis factor inhibitor (anti-TNF) use was associated with a reduced odds of hospitalisation (OR 0.40, 95% CI 0.19 to 0.81), while no association with antimalarial use (OR 0.94, 95% CI 0.57 to 1.57) was observed. Conclusions We found that glucocorticoid exposure of ≥10 mg/day is associated with a higher odds of hospitalisation and anti-TNF with a decreased odds of hospitalisation in patients with rheumatic disease. Neither exposure to DMARDs nor NSAIDs were associated with increased odds of hospitalisation.read more
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Recommendations for the management of patients with systemic rheumatic diseases during the coronavirus disease pandemic
Mi Ryoung Seo,Ji-Won Kim,Eun Jung Park,Seung Min Jung,Yoon-Kyoung Sung,Hyung-Jin Kim,Gunwoo Kim,Hyun-Sook Kim,Myeung-Su Lee,Jisoo Lee,Ji An Hur,Bum Sik Chin,Joong Sik Eom,Han Joo Baek +13 more
TL;DR: The Korean College of Rheumatology recognized the urgent need to develop recommendations for rheumatologists and other physicians to manage patients with SRD during the COVID-19 pandemic and developed four general principles and thirteen individual recommendations based on the available evidence.
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COVID-19 in Association With Development, Course, and Treatment of Systemic Autoimmune Rheumatic Diseases.
Katja Lakota,Katja Perdan-Pirkmajer,Katja Perdan-Pirkmajer,Alojzija Hočevar,Alojzija Hočevar,Snezna Sodin-Semrl,Snezna Sodin-Semrl,Žiga Rotar,Žiga Rotar,Saša Čučnik,Saša Čučnik,Polona Žigon,Polona Žigon +12 more
TL;DR: In this paper, the authors found that the risk of SARS-CoV-2 infection in patients with a systemic autoimmune rheumatic disease (SARD) appears slightly higher compared to the general population and the course of COVID-19 disease does not seem to be very different.
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Outcome of COVID-19 in hospitalized patients with chronic inflammatory diseases. A population based national register study in Denmark.
Jens Kjeldsen,Jens Kjeldsen,Jan Nielsen,Torkell Ellingsen,Torben Knudsen,Rasmus Nielsen,Michael Larsen,Ken Lund,Bente Mertz Nørgård +8 more
TL;DR: In this article, the authors studied whether hospitalized patients with COVID-19 and chronic inflammatory diseases experienced worse outcomes compared to patients hospitalized with patients without chronic inflammatory disease, and found that the morbidity and mortality was substantially higher in patients who were admitted to hospital with these conditions.
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Challenges of autoimmune rheumatic disease treatment during the COVID-19 pandemic: A review.
TL;DR: There is no evidence of a higher incidence of COVID in patients with autoimmune rheumatic diseases and the approach of maintaining chronic rheumatological treatments is supported, however, once infected there is a small but significant increased risk of mortality.
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Use of hydroxychloroquine for pre-exposure prophylaxis in COVID 19: debate and suggested future course.
TL;DR: The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2 has brought the entire world to a halt and there is an urgent need for effective prevent...
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