Characterization of Novel Cysteine-rich Antimicrobial Peptides from Scorpion Blood
Laurence Ehret-Sabatier,Damarys Loew,Max Goyffon,Pascale Fehlbaum,Jules A. Hoffmann,Alain Van Dorsselaer,Philippe Bulet +6 more
TLDR
Three distinct antimicrobial peptides are isolated from the hemolymph of unchallenged scorpions of the species Androctonus australis, which are fully characterized by Edman degradation, electrospray ionization mass spectrometry, and matrix-assisted laser desorption/ionization mass Spectrometry.About:
This article is published in Journal of Biological Chemistry.The article was published on 1996-11-22 and is currently open access. It has received 210 citations till now. The article focuses on the topics: Edman degradation & Electrospray ionization.read more
Citations
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Anti-microbial peptides: from invertebrates to vertebrates
TL;DR: This review focuses on AMPs forming α‐helices, β‐hairpin‐like β‐sheets, α‐helix/β‐sheet mixed structures from invertebrate and vertebrate origins, which show some promise for therapeutic use.
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Antimicrobial peptides in insects; structure and function
TL;DR: This review presents the main results obtained during the last four years in the field of antimicrobial peptides from insects with a special focus on the proline-rich and cysteine-rich peptides.
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Antimicrobial peptides: premises and promises.
TL;DR: Peptides, namely magainin and nisin have been shown to demonstrate contraceptive properties in vitro and in vivo and a few peptides have already entered clinical trials for the treatment of impetigo, diabetic foot ulcers and gastric helicobacter infections.
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The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms
Bryan G. Fry,Kim Roelants,Donald E. Champagne,Holger Scheib,Joel D. A. Tyndall,Glenn F. King,Timo J. Nevalainen,Janette A Norman,Richard J. Lewis,Raymond S. Norton,Raymond S. Norton,Camila Renjifo,Ricardo C. Rodríguez de la Vega +12 more
TL;DR: A number of overarching structural, functional, and evolutionary generalities of the protein families from which these toxins have been frequently recruited are discussed and a revised and expanded working definition for venom is proposed.
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Animal antimicrobial peptides: an overview.
David Andreu,Luis Rivas +1 more
TL;DR: This review provides a general introduction to the subject of antimicrobial peptides, with emphasis on aspects such as structural types, post-translational modifications, mode of action or mechanisms of resistance.
References
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Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle
TL;DR: A protein inhibitor of single Ca2+-activated K+ channels of mammalian skeletal muscle is described, a minor component of the venom of the Israeli scorpion, Leiurus quinquestriatus, reversibly blocks the large Ca2- activated K+ channel in a simple bimolecular reaction.
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Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus.
Antonio Gálvez,Guillermo Giménez-Gallego,J P Reuben,L Roy-Contancin,P Feigenbaum,Gregory J. Kaczorowski,Maria L. Garcia +6 more
TL;DR: Data suggest that IbTX interacts at a distinct site on the channel and modulates ChTX binding by an allosteric mechanism, which defines a new class of peptidyl inhibitor of PK,Ca with unique properties that make it useful for investigating the characteristics of this channel in target tissues.
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A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis.
TL;DR: Synthesis and cleavage of 10 peptides demonstrated the complementarity of Fmoc chemistry with Reagent K for efficient synthesis of complex peptides and assessed the relative effectiveness of various scavengers in suppressing side reactions.
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Innate immunity of insects
TL;DR: The powerful techniques developed to study the genetics of Drosophila provide a unique opportunity to dissect the development and differentiation of this primordial immune system and may contribute to the understanding of the innate immune response in higher organisms.
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Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure.
Takahiro Nakamura,H. Furunaka,Toshiyuki Miyata,Fuminori Tokunaga,Tsuyoshi Muta,Sadaaki Iwanaga,M Niwa,Toshifumi Takao,Y. Shimonishi +8 more
TL;DR: Tachyplesin seems likely to act as antimicrobial peptide for self-defense in the horseshoe crab against invading microorganisms.