Innate Immunity: ISOLATION OF SEVERAL CYSTEINE-RICH ANTIMICROBIAL PEPTIDES FROM THE BLOOD OF A MOLLUSC, MYTILUS EDULIS
Maurice Charlet,Serguey Chernysh,Hervé Philippe,Charles Hetru,Jules A. Hoffmann,Philippe Bulet +5 more
TLDR
It is argued that circulating antimicrobial peptides represent an ancient host defense mechanism that predated the separation between molluscs and arthropods at the root of the Cambrian, about 545 million years ago.About:
This article is published in Journal of Biological Chemistry.The article was published on 1996-09-06 and is currently open access. It has received 359 citations till now. The article focuses on the topics: Antimicrobial peptides & Myticin.read more
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Marine natural products.
TL;DR: This review covers the literature published in 2014 for marine natural products, with 1116 citations referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms.
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Anti-microbial peptides: from invertebrates to vertebrates
TL;DR: This review focuses on AMPs forming α‐helices, β‐hairpin‐like β‐sheets, α‐helix/β‐sheet mixed structures from invertebrate and vertebrate origins, which show some promise for therapeutic use.
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Antimicrobial peptides in insects; structure and function
TL;DR: This review presents the main results obtained during the last four years in the field of antimicrobial peptides from insects with a special focus on the proline-rich and cysteine-rich peptides.
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Antimicrobial peptides: premises and promises.
TL;DR: Peptides, namely magainin and nisin have been shown to demonstrate contraceptive properties in vitro and in vivo and a few peptides have already entered clinical trials for the treatment of impetigo, diabetic foot ulcers and gastric helicobacter infections.
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Antimicrobial peptides: key components of the innate immune system
TL;DR: An overview of cationic antimicrobial peptides, origin, structure, functions, and mode of action of AMPs, which are highly expressed and found in humans, as well as a brief discussion about widely abundant, well characterized AMPs in mammals.
References
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Confidence limits on phylogenies: an approach using the bootstrap.
TL;DR: The recently‐developed statistical method known as the “bootstrap” can be used to place confidence intervals on phylogenies and shows significant evidence for a group if it is defined by three or more characters.
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Plant defensins: novel antimicrobial peptides as components of the host defense system.
TL;DR: A novel class of plant peptides whose structural and functional properties resemble those of insect and mammalian defensins are characterized, which are one class among the numerous types of Cys-rich antimicrobial peptides.
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MUST, a computer package of Management Utilities for Sequences and Trees
TL;DR: The MUST package is a phylogenetically oriented set of programs for data management and display, allowing one to handle both raw data (sequences) and results (trees, number of steps, bootstrap proportions).
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A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
Bruno Lemaitre,Elisabeth Kromer-Metzger,Lydia Michaut,Emmanuelle Nicolas,Marie Meister,Philippe Georgel,Jean-Marc Reichhart,Jules A. Hoffmann +7 more
TL;DR: It is reported that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background, and the results point to the existence of two different pathways leading to the expression of two types of target genes.
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Innate immunity of insects
TL;DR: The powerful techniques developed to study the genetics of Drosophila provide a unique opportunity to dissect the development and differentiation of this primordial immune system and may contribute to the understanding of the innate immune response in higher organisms.