Characterization of the gut microbiota in hemodialysis patients with sarcopenia.
TLDR
Wang et al. as discussed by the authors used 16S rRNA sequencing technology to analyze the genetic sequence of the gut microbiota for evaluation of the diversity, species composition, and differential microbiota of the two groups.Abstract:
Purpose Maintenance hemodialysis (MHD) patients are at high risk of sarcopenia. Gut microbiota affects host metabolic and may act in the occurrence of sarcopenia importantly. This study aimed to study the characterization of the gut microbiota in MHD patients with sarcopenia, and to further reveal the complex pathophysiology of sarcopenia in MHD patients. Methods Fecal samples and clinical data were collected from 30 MHD patients with sarcopenia, and 30 age-and-sex-matched MHD patients without sarcopenia in 1 general hospital of Jiangsu Province from December 2020 to March 2021. 16S rRNA sequencing technology was used to analyze the genetic sequence of the gut microbiota for evaluation of the diversity, species composition, and differential microbiota of the two groups. Results Compared to MHD patients without sarcopenia, the ACE index of patients with sarcopenia was lower (P = 0.014), and there was a structural difference in the β-diversity between the two groups (P = 0.001). At the genus level, the relative abundance of Tyzzerella_4 in the sarcopenia group was significantly higher than in the non-sarcopenia group (P = 0.039), and the relative abundance of Megamonas (P = 0.004), Coprococcus_2 (P = 0.038), and uncultured_bacterium_f_Muribaculaceae (P = 0.040) decreased significantly. Conclusion The diversity and structure of the gut microbiota of MHD patients with sarcopenia were altered. The occurrence of sarcopenia in MHD patients may be influenced by gut microbiota.read more
Citations
More filters
Journal ArticleDOI
Population‐based metagenomics analysis reveals altered gut microbiome in sarcopenia: data from the Xiangya Sarcopenia Study
Yilun Wang,Yuqing Zhang,Nancy E Lane,Jing Wu,Tuo Yang,Jiatian Li,Hongyi He,Jie Wei,Chao Zeng,Guanghua Lei +9 more
TL;DR: Shooting shotgun metagenomic sequencing was performed to compare the gut microbiome composition and function between individuals with and without sarcopenia.
Journal ArticleDOI
Intestinal microbiome in normal ageing, frailty and cognition decline
TL;DR: In this paper , the authors provided an update on the influence of the gut microbiota on physical and cognitive performance in older adults and suggested microbiota-targeted interventions for healthy ageing, especially from a clinical point of view.
Journal ArticleDOI
Melatonin improves the homeostasis of mice gut microbiota rhythm caused by sleep restriction.
TL;DR: In this paper , the authors showed that chronic sleep loss disrupts the pattern of colonic microbial communities and reduces the proportion of gut microbiota with a circadian rhythm, with concomitant changes in the peak phase of the KEGG pathway.
References
More filters
Journal ArticleDOI
Diversity, stability and resilience of the human gut microbiota
Catherine A. Lozupone,Jesse Stombaugh,Jeffrey I. Gordon,Janet K. Jansson,Rob Knight,Rob Knight +5 more
TL;DR: Viewing the microbiota from an ecological perspective could provide insight into how to promote health by targeting this microbial community in clinical treatments.
Journal ArticleDOI
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
TL;DR: Data is reviewed supporting the diverse functional roles carried out by a major class of bacterial metabolites, the short-chain fatty acids (SCFAs), which affect various physiological processes and may contribute to health and disease.
Journal ArticleDOI
Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment
Liang Kung Chen,Jean Woo,Prasert Assantachai,Tung Wai Auyeung,Ming Yueh Chou,Katsuya Iijima,Hak Chul Jang,Lin Kang,Miji Kim,Sunyoung Kim,Taro Kojima,Masafumi Kuzuya,Jenny S.W. Lee,Sang Yoon Lee,Wei Ju Lee,Yunhwan Lee,Chih Kuang Liang,Jae Young Lim,Wee Shiong Lim,Li Ning Peng,Ken Sugimoto,Tomoki Tanaka,Chang Won Won,Minoru Yamada,Teimei Zhang,Masahiro Akishita,Hidenori Arai +26 more
TL;DR: The Asian Working Group for Sarcopenia 2019 introduces "possible sarcopenia," defined by either low muscle strength or low physical performance only, specifically for use in primary health care or community-based health promotion, to enable earlier lifestyle interventions.
Journal ArticleDOI
Sarcopenia and Physical Frailty: Two Sides of the Same Coin
TL;DR: Since the last decade, geriatrics and geron-tology researchers have been devoting anincreasing amount of efforts in the attempt of designing, developing, and implement-ing preventive interventions against con-ditions determining/driving the disabling cascade of conditions, including sarcopenia and frailty.
Journal ArticleDOI
Human gut microbiota/microbiome in health and diseases: a review
TL;DR: The role of gut microbiota in maintaining host health is clarified and how nutritional and environmental factors affect the gut microbial structure and function is investigated.