Journal ArticleDOI
Characterization of thermal behavior of deep eutectic solvents and their potential as drug solubilization vehicles.
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TLDR
Deep eutectic solvent can be a promising vehicle for increasing exposure of poorly soluble compounds in preclinical studies and in solubility in DES is 5 to 22,000 folds more than that in water.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2009-08-13. It has received 417 citations till now. The article focuses on the topics: Deep eutectic solvent & Chloride.read more
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Deep Eutectic Solvents (DESs) and Their Applications
Journal ArticleDOI
Deep eutectic solvents: syntheses, properties and applications
TL;DR: All works discussed in this review aim at demonstrating that Deep Eutectic Solvents not only allow the design of eco-efficient processes but also open a straightforward access to new chemicals and materials.
Journal ArticleDOI
Natural Deep Eutectic Solvents – Solvents for the 21st Century
Alexandre Paiva,Rita Craveiro,Ivo Manuel Ascensão Aroso,Marta Martins,Rui L. Reis,Ana Rita C. Duarte +5 more
TL;DR: Deep Eutectic Solvents (DES) as discussed by the authors are a class of solvents that can be defined as a mixture of two or more components, which at a particular composition present a high melting point depression becoming liquids at room temperature.
Journal ArticleDOI
Low-transition-temperature mixtures (LTTMs): a new generation of designer solvents.
TL;DR: A new generation of designer solvents emerged in the last decade as promising green media for multiple applications, including separation processes: the low-transition-temperature mixtures (LTTMs).
Journal ArticleDOI
Deep Eutectic Solvents: A Review of Fundamentals and Applications.
Benworth Hansen,Stephanie Spittle,Brian Chen,Derrick Poe,Yong Zhang,Jeffrey M. Klein,Alexandre Horton,Laxmi Adhikari,Tamar Zelovich,Brian W. Doherty,Burcu Gurkan,Edward J. Maginn,Arthur J. Ragauskas,Mark Dadmun,Thomas A. Zawodzinski,Gary A. Baker,Mark E. Tuckerman,Robert F. Savinell,Joshua Sangoro +18 more
TL;DR: A detailed review of the current literature reveals the lack of predictive understanding of the microscopic mechanisms that govern the structure-property relationships in deep eutectic solvents, and highlights recent research efforts to elucidate the next steps needed to develop a fundamental framework needed for a deeper understanding.
References
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Journal ArticleDOI
Ionic Liquids-New "Solutions" for Transition Metal Catalysis.
Peter Wasserscheid,Wilhelm Keim +1 more
TL;DR: There are indications that switching from a normal organic solvent to an ionic liquid can lead to novel and unusual chemical reactivity, which opens up a wide field for future investigations into this new class of solvents in catalytic applications.
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Novel solvent properties of choline chloride/urea mixtures
TL;DR: Eutectic mixtures of urea and a range of quaternary ammonium salts are liquid at ambient temperatures and have interesting solvent properties.
Book
Ionic Liquids in Synthesis
Peter Wasserscheid,Tom Welton +1 more
TL;DR: The early years of Ionic liquid production were covered in this article, where a new generation of soluble supports for Supported Organic Synthesis (SPOS) was proposed. But this support was not applied to the task-specific Ionic liquids.
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Deep Eutectic Solvents Formed between Choline Chloride and Carboxylic Acids: Versatile Alternatives to Ionic Liquids
TL;DR: It is shown that the conductivity and viscosity of these liquids is controlled by ion mobility and the availability of voids of suitable dimensions, and this is consistent with the fluidity of other ionic liquids and molten salts.