Chemical foundations of hydrogen sulfide biology.
Qian Li,Jack R. Lancaster +1 more
TLDR
This review focuses on the chemistry between H2S and its three potential biological targets: oxidants, metals and thiol derivatives, discusses the applications of these basics into H 2S biology and methodology, and introduces the standard terminology to this youthful field.About:
This article is published in Nitric Oxide.The article was published on 2013-11-30 and is currently open access. It has received 266 citations till now.read more
Citations
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Journal ArticleDOI
Chemical Biology of H2S Signaling through Persulfidation.
TL;DR: The biologically relevant chemistry of H2S and the enzymatic routes for its production and oxidation are discussed and the roles ascribed to protein persulfidation in cell signaling pathways are discussed.
Journal ArticleDOI
Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways
TL;DR: It is posited that sulfide oxidation pathways mediate sulfide signaling and that sulfurtransferases ensure target specificity and that sulfides, polysulfides and thiosulfate generate a series of reactive sulfur species that could modify target proteins.
Journal ArticleDOI
Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility.
Katsuhiko Ono,Takaaki Akaike,Tomohiro Sawa,Yoshito Kumagai,David A. Wink,Dean J. Tantillo,Adrian J. Hobbs,Péter Nagy,Ming Xian,Joseph Lin,Jon M. Fukuto +10 more
TL;DR: The basic chemical biology of H2S as well as other related or derived species is discussed and reviewed, and this review particularly focuses on the per- and polysulfides which are likely in equilibrium with free H 2S and which may be important biological effectors themselves.
Journal ArticleDOI
Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications.
Yu Zhao,Tyler D. Biggs,Ming Xian +2 more
TL;DR: The developments and limitations of currently available donors including H2S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids are summarized.
Journal ArticleDOI
Fluorescent probes for the simultaneous detection of multiple analytes in biology
TL;DR: This work reviews work that has been carried out to date, and suggests future research directions that will harness the considerable potential of dual-responsive fluorescent probes.
References
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Book
CRC Handbook of Chemistry and Physics
TL;DR: CRC handbook of chemistry and physics, CRC Handbook of Chemistry and Physics, CRC handbook as discussed by the authors, CRC Handbook for Chemistry and Physiology, CRC Handbook for Physics,
Journal ArticleDOI
The reaction of no with superoxide
Robert E. Huie,S. Padmaja +1 more
TL;DR: The rate constant for the reaction of NO with .O2- was determined to be (6.7 +/- 0.9) x 10(9) l mol-1 s-1, considerably higher than previously reported.
Journal ArticleDOI
H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Guangdong Yang,Guangdong Yang,Lingyun Wu,Bo Jiang,Wei Yang,Jiansong Qi,Kun Cao,Qinghe Meng,Asif K. Mustafa,Weitong Mu,Shengming Zhang,Solomon H. Snyder,Rui Wang,Rui Wang +13 more
TL;DR: It is shown that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues.
Journal ArticleDOI
The possible role of hydrogen sulfide as an endogenous neuromodulator
Kazuho Abe,Hideo Kimura +1 more
TL;DR: It is shown that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation, suggesting that endogenous H 2S functions as a neuromodulator in the brain.
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The possible role of hydrogen sulfide as an endogenous neuromodulator
Kazuho Abe,Hideo Kimura +1 more