Showing papers in "Nitric Oxide in 2013"

TL;DR: Recent understanding of H2S chemical biology, its relationship to tissue pathophysiological responses and possible therapeutic uses are discussed.

TL;DR: This review focuses on the chemistry between H2S and its three potential biological targets: oxidants, metals and thiol derivatives, discusses the applications of these basics into H 2S biology and methodology, and introduces the standard terminology to this youthful field.

TL;DR: Hydrogen sulfide can serve as an alternative source of sulfur for plants, which may be significant in anaerobic conditions of waterlogged soils and in the widely discussed sulfur-induced-resistance/sulfur-enhanced-defense.

TL;DR: New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.

TL;DR: An overview of ongoing studies in the author's laboratory exploring new photochemical NO precursors including those with nanomaterial antennas designed to enhance the effectiveness of these precursor with longer excitation wavelengths are presented.

TL;DR: The SIRT1/FOXO factor axis is involved in resveratrol-induced eNOS transcriptional activation and enhances the expression and activity of FOXO transcription factors.

TL;DR: This review critically analyzes the impact of O2 tension, pH, substrate concentrations, glycoaminoglycan docking and inhibition strategies on the nitrite reductase activity of XOR and reveals a hypoxic milieu where this process may be operative.

TL;DR: The latest advances in understanding the effects of endogenous NO on heavy metal toxicity and the mechanisms and role of NO as an antioxidant as well as in protein nitration are highlighted.

TL;DR: It is demonstrated that H2S production in HCT116 cells is stimulated by the allosteric CBS activator, SAM, which serves as an endogenous cancer cell growth and bioenergetic factor at low-to intermediate levels and early time periods.

TL;DR: It is suggested that uric acid decreased eNOS activity and NO production through reducing the binding between eN OS and CaM in EC and this result may provide molecular mechanism by which uric Acid induces endothelial dysfunction.

TL;DR: The results showed that the efficacy of PDT is strengthened when the photosensitizer is used in combination with an NO donor.

TL;DR: In this article, the acute effects of a nitrate-rich meal containing spinach on arterial stiffness and blood pressure in healthy men and women were assessed, and the results showed that spinach resulted in an eightfold increase in salivary nitrite and a sevenfold increase of salivial nitrate concentrations from pre-meal to 120min post meal.

TL;DR: SO2 preconditioning could significantly reduce I/R-induced myocardial injury in vivo in association with increased myocardian antioxidative capacity, upregulated myocardia H2S/CSE pathway but downregulated NO/iNOS pathway.

TL;DR: In silico analysis of the pea CA protein sequence suggests that Tyr(205) is the most likely potential target for nitration, and the CA activity was inhibited by 41%.

TL;DR: Data indicate that diphenyl diselenide (PhSe)₂ protects BAEC against peroxynitrite-mediated cell damage not by a direct reaction, but rather by increasing cellular GPx expression as a consequence of enhanced nuclear translocation of Nrf-2, which together with the increase in intracellular GSH, may work catalytically to reduce peroxlynitrite to nitrite.

TL;DR: It has been found that heating of solutions of the binuclear form of dinitrosyl iron complexes with glutathione in a degassed Thunberg apparatus results in their decomposition with a concomitant release of four gaseous NO molecules per one B-DNIC.

TL;DR: Treatment of drug-resistant human prostate carcinoma cell lines with high levels of the NO-donor DETANONOate sensitized the resistant tumor cells to apoptosis by CDDP and the combination was synergistic, suggesting that one mechanism of DETANonOate-induced sensitization of resistant tumors to CDDP correlated with the inhibition of NF-κB and its targets YY1 and BclXL.

TL;DR: Results suggest that increased CYP4A1 expression and 20-HETE formation associated with suppression of iNOS/sGC/PKG pathway, COX-2, and gp91(phox) participate in the protective effect of 5,14-HEDGE against vasodilation, hypotension, tachycardia, and inflammation in the rat model of septic shock.

TL;DR: A combination of mathematical modeling and experimentation is utilized to elucidate the kinetics of NO/DAF-FM reaction in solution and the derived rate law can be used for the calibration of DAF-FM fluorescence and the quantification of NO concentration in biological tissues.

TL;DR: Better understanding of the molecular basis for the formation, signaling functions, and metabolisms of 8-nitro-cGMP would be useful for the development of new diagnostic approaches and treatment of diseases related to oxidative stress and redox metabolisms.

TL;DR: It is demonstrated that gomisin N and γ-schizandrin are involved in the hepatoprotective effect of the FSC extract, which has therapeutic potential for liver disease.

TL;DR: The present findings indicate that A. melanocarpa juice is a potent stimulator of the endothelial formation of NO in coronary arteries; this effect involves the phosphorylation of eNOS via the redox-sensitive activation of the Src/PI3-kinase/Akt pathway mostly by conjugated cyanidins and chlorogenic acids.

TL;DR: RBC membranes show bubble formation of the phospholipid layer, as well as balloon-like smooth areas; while their general discoid shapes are changed to form pointed extensions; and membrane roughness is investigated using atomic force microscopy and these results confirm SEM results.

TL;DR: It is suggested, that NO donors have the potential to act as anti-tumoral agent through inhibiting cancer cell signaling and reducing their viability.

TL;DR: The results suggest that 80 and 160ppm gNO have a time dependent antiviral effect on influenza strains of viruses during various stages of cellular infection, which are not due to concomitant changes in pH in the surrounding milieu.

TL;DR: Investigation of the effects of β-sitosterol on insulin sensitivity, oxidative and nitrosative stress and lipid abnormalities in liver of high fat-fed rat model of insulin resistance (IR) and whether nitric oxide is involved in its action found it promotes insulin sensitivity in rats fed HFD possibly by improving NO levels.

TL;DR: It is suggested that high ADMA levels in early sPE could compromise NO synthesis contributing to endothelial dysfunction, leading to impaired placentation and the onset of this disease.

TL;DR: B-DNIC preparations synthesized by using new method contain negligible amount of nitrite or S-nitrosoglutathione as a contaminations, and a long-lasting hypotensive action of DNIC formed was demonstrated.

TL;DR: Differences in differences in activation of genes involved in sensing and responding to oxidative/nitrosative stress, including the early-immediate c-Fos gene and the phase II antioxidant enzyme, heme oxygenase-1, was diminished in neuroglobin-overexpressing compared to wild-type neurons.

TL;DR: It is shown that adenine radicals also react with NO to form hypoxanthine and 8-azaadenine, which in dividing cells may induce the formation of stalled replication forks and as a consequence replication-induced DNA strand breaks which may lead to cell death.