Journal ArticleDOI
Chemical hormesis: its historical foundations as a biological hypothesis.
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TLDR
The early history of hormesis-related experimental research is reconstructed and a foundation is provided for the assessment of how the concept of hormetic dose-response relationships may have affected the nature of the bioassay especially with respect to hazard assessment practices within a modern risk assessment Eramework.Abstract:
Despite the long history of hormesis-related experimental research no systematic effort to describe its early history has been undertaken. The present paper attempts to reconstruct and assess the early history of such research and to evaluate how advances in related scientific fields affected the course of hormesis-related research. The purpose of this paper is not only to satisfy this gap in current knowledge, but also to provide a foundation for the assessment of how the concept of hormetic dose-response relationships may have affected the nature of the bioassay especially with respect to hazard assessment practices within a modern risk assessment framework.read more
Citations
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Journal ArticleDOI
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
Edward J. Calabrese,Kenneth Bachmann,A. John Bailer,P. Michael Bolger,Jonathan Borak,Lu Cai,Nina Cedergreen,M. George Cherian,Chuang Chin Chiueh,Thomas W. Clarkson,Ralph R. Cook,David M. Diamond,David J. Doolittle,Michael A. Dorato,Stephen O. Duke,Ludwig E. Feinendegen,Donald E. Gardner,Ronald W. Hart,Kenneth L. Hastings,A. Wallace Hayes,George R. Hoffmann,John A. Ives,Zbigniew Jaworowski,Thomas E. Johnson,Wayne B. Jonas,Norbert E. Kaminski,John G. Keller,James E. Klaunig,Thomas B. Knudsen,Walter J. Kozumbo,Teresa Lettieri,Shu Zheng Liu,Andre Maisseu,Kenneth I. Maynard,Edward J. Masoro,Roger O. McClellan,Harihara M. Mehendale,Carmel Mothersill,David B. Newlin,Herbert N. Nigg,Frederick W. Oehme,Robert F. Phalen,Martin A. Philbert,Suresh I. S. Rattan,Jim E. Riviere,Joseph Rodricks,Robert M. Sapolsky,Bobby R. Scott,Colin Seymour,David A. Sinclair,Joan Smith-Sonneborn,Elizabeth T. Snow,Linda P. Spear,Donald E. Stevenson,Yolene Thomas,Maurice Tubiana,Gary M. Williams,Mark P. Mattson +57 more
TL;DR: This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
Journal ArticleDOI
Toxicology rethinks its central belief
TL;DR: Hormesis demands a reappraisal of the way risks are assessed for the first time in 25 years.
Journal ArticleDOI
Hormesis: why it is important to toxicology and toxicologists.
TL;DR: The article indicates that the hormetic dose response is the most fundamental dose response, significantly outcompeting other leading dose-response models in large-scale, head-to-head evaluations.
Journal ArticleDOI
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders
Vittorio Calabrese,Carolin Cornelius,Albena T. Dinkova-Kostova,Albena T. Dinkova-Kostova,Edward J. Calabrese,Mark P. Mattson +5 more
TL;DR: It is argued that the hormetic dose response provides the central underpinning of neuroprotective responses, providing a framework for explaining the common quantitative features of their dose-response relationships, their mechanistic foundations, and their relationship to the concept of biological plasticity.
Journal ArticleDOI
Hormesis: The Dose-Response Revolution
TL;DR: Hormesis, a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition, has been frequently observed in properly designed studies and is broadly generalizable as being independent of chemical/physical agent, biological model, and endpoint measured.
References
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Book
The rise of statistical thinking, 1820-1900
TL;DR: In this paper, Porter describes the background that produced the burst of modern statistical innovation of the early 1900s, emphasizing the debt of science to nonspecialist intellectuals, and the pioneering statistical physicists and biologists, Maxwell, Boltzmann, and Galton, each pointed to analogies between his discipline and social science.
Journal ArticleDOI
Hormesis--the stimulation of growth by low levels of inhibitors.
TL;DR: Evidence from the literature shows that not only has growth hormesis been observed in a range of taxa after exposure to a variety of agents, but also that the dose-response data have a consistent form.
Journal ArticleDOI
The Dose Determines the Stimulation (and Poison): Development of A Chemical Hormesis Database:
TL;DR: The present analysis suggests that chemical hormesis is a reproducible and generalizable biologic phenomenon that can be explained in multiple biologic systems with various endpoints.
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