Journal ArticleDOI
Chemopreventive effects of diverse dietary phytochemicals against DMBA-induced hamster buccal pouch carcinogenesis via the induction of Nrf2-mediated cytoprotective antioxidant, detoxification, and DNA repair enzymes.
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TLDR
There is substantial evidence that the dietary phytochemicals inhibit the development of HBP carcinomas through the activation of Nrf2/Keap-1 signaling and by upregulating cytoprotective enzymes.About:
This article is published in Biochimie.The article was published on 2013-08-01. It has received 63 citations till now. The article focuses on the topics: DMBA & Antioxidant.read more
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Ellagic acid: Pharmacological activities and molecular mechanisms involved in liver protection
TL;DR: This is the first review focused on the pharmacological properties and on the molecular mechanisms activated by EA in terms of liver protection, and the use of new delivery systems that enhances EA bioavailability would improve the results already obtained.
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Dietary regulation of Keap1/Nrf2/ARE pathway: focus on plant-derived compounds and trace minerals.
TL;DR: Priming the Keap1/Nrf2/ARE pathway by upregulating these enzymes prior to oxidative stress or xenobiotic encounter increases cellular fitness to respond more robustly to oxidative assaults without activating more intense inflammatory NFκB-mediated responses.
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The Nrf2-ARE signaling pathway: An update on its regulation and possible role in cancer prevention and treatment.
TL;DR: A critical evaluation of currently available Nrf2 inducers and inhibitors is presented and growing evidence indicates that the regulation of Keap1-Nrf2-ARE is more complex than was previously thought and that other molecular mechanisms are also involved.
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Carotenoids and Chlorophylls as Antioxidants
TL;DR: Different approaches used to obtain a physiological perspective are discussed, from in vitro studies to in vivo assays using oxidative biomarkers, and a promising era is coming where the term “antioxidant” is understood in terms of its broadest significance.
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Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application
TL;DR: Clinical applications to alter detoxification pathway activity and improve patient outcomes are considered, drawing on the growing understanding of the relationship between detoxification functions and different disease states, genetic polymorphisms, and drug-nutrient interactions.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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Cancer chemoprevention with dietary phytochemicals
TL;DR: Attention has recently been focused on intracellular-signalling cascades as common molecular targets for various chemopreventive phytochemicals.
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8-hydroxy-2' -deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis.
TL;DR: The biomarker 8-OHdG or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis and has been used to estimate the DNA damage in humans after exposure to cancer-causing agents.
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Nrf2:INrf2 (Keap1) signaling in oxidative stress.
TL;DR: The switching on and off of Nrf2 protects cells against free radical damage, prevents apoptosis, and promotes cell survival, and is a mechanism of critical importance for cellular protection and cell survival.
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NRF2 and cancer: the good, the bad and the importance of context
Michael B. Sporn,Karen T. Liby +1 more
TL;DR: This Opinion article aims to rationalize conflicting perspectives by critiquing the context dependence of NRF2 functions and the experimental methods behind these conflicting data.