Chitosan Modification and Pharmaceutical/Biomedical Applications
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This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on achievements as well as the domestic and overseas developments.Abstract:
Chitosan has received much attention as a functional biopolymer for diverse applications, especially in pharmaceutics and medicine. Our recent efforts focused on the chemical and biological modification of chitosan in order to increase its solubility in aqueous solutions and absorbability in the in vivo system, thus for a better use of chitosan. This review summarizes chitosan modification and its pharmaceutical/biomedical applications based on our achievements as well as the domestic and overseas developments: (1) enzymatic preparation of low molecular weight chitosans/chitooligosaccharides with their hypocholesterolemic and immuno-modulating effects; (2) the effects of chitin, chitosan and their derivatives on blood hemostasis; and (3) synthesis of a non-toxic ion ligand—D-Glucosaminic acid from Oxidation of D-Glucosamine for cancer and diabetes therapy.read more
Citations
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Industrial applications of crustacean by-products (chitin, chitosan, and chitooligosaccharides): A review
TL;DR: In this paper, a review summarizes the current state of knowledge of these crustacean shellfish shellfish wastes and the various ways to use chitin, a polysaccharide that may be extracted after deproteinisation and demineralization of the exoskeletons.
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Chitosan-based nanomaterials: A state-of-the-art review
TL;DR: Chitosan based nanomaterials have superior physical and chemical properties such as high surface area, porosity, tensile strength, conductivity, photo-luminescent as well as increased mechanical properties as comparison to pure chitOSan.
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Antibacterial activity of chitin, chitosan and its oligomers prepared from shrimp shell waste
TL;DR: The antimicrobial activities of chito-oligosaccharides against four Gram-positive and seven Gram-negative bacteria were compared to chitosan and chitin with an emphasis on the effects of biopolymer molecular weight (Mv) and degree of deacetylation (DD).
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Chitosan as biomaterial in drug delivery and tissue engineering.
Saad M. Ahsan,Mathai Thomas,Kranthi K. Reddy,Sujata Gopal Sooraparaju,Amit Asthana,Ira Bhatnagar +5 more
TL;DR: The present article has tried to review the latest research on chitosan based tissue engineering constructs, drug delivery vehicles as well as dental care products to pave a way for future applications in the field of biomedical innovation and regenerative medicine.
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A review of bioactive plant polysaccharides: Biological activities, functionalization, and biomedical applications
TL;DR: The main goal of this paper was to review the sources, natively biological activities, isolation, characterization, and the structural features of natively bioactive polysaccharides from wood species to maximally exploit their various valuable properties in previously unperceived applications.
References
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Chitin and chitosan: Properties and applications
TL;DR: Chitin is the second most important natural polymer in the world as mentioned in this paper, and the main sources of chitin are two marine crustaceans, shrimp and crabs, which are used for food, cosmetics, biomedical and pharmaceutical applications.
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Chitosan chemistry and pharmaceutical perspectives.
TL;DR: Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. S. Nagar, Punjab-160 062, India, Institute of Biochemistry, Faculty of Medicine, Polytechnic University, Via Ranieri 67, IT-60100 Ancona, Italy, and Department of Medicinal Chemistry & Natural Products,The Hebrew University of Jerusalem, School of Pharmacy-Faculty of medicine, Jerusalem 91120, Israel.
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Food applications of chitin and chitosans
TL;DR: Application of chitinous products in foods and pharmaceuticals as well as processing aids has received considerable attention in recent years as exotic synthetic compounds are losing their appeal.
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Chitin/chitosan: modifications and their unlimited application potential—an overview
TL;DR: The net cationicity as well as the presence of multiple reactive functional groups in the molecule make chitosan a sought-after biomolecule and offers scope for manipulation for preparing a broad spectrum of derivatives for specific end use applications in diversified areas.
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Chitins and chitosans for the repair of wounded skin, nerve, cartilage and bone
TL;DR: The introduction of azido functions in chitosan has provided photo-sensitive hydrogels for surgical use as coatings, scaffolds, drug carriers and implants capable to deliver cells and growth factors, which remain unmatched by other polysaccharides.