Cholesterol-lowering efficacy of a microencapsulated bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 yoghurt formulation in hypercholesterolaemic adults.
TLDR
Results show that consumption of microencapsulated BSH-active L. reuteri NCIMB 30242 yoghurt is efficacious and safe for lowering LDL-C, TC, apoB-100 and non-HDL-C in hypercholesterolaemic subjects.Abstract:
Several studies have reported limited or no reduction in serum cholesterol in response to probiotic formulations. Recently, probiotics have shown promise in treating metabolic disease due to improved strain selection and delivery technologies. The aim of the present study was to evaluate the cholesterol-lowering efficacy of a yoghurt formulation containing microencapsulated bile salt hydrolase (BSH)-active Lactobacillus reuteri NCIMB 30242, taken twice per d over 6 weeks, in hypercholesterolaemic adults. A total of 114 subjects completed this double-blind, placebo-controlled, randomised, parallel-arm, multi-centre study. This interventional study included a 2-week washout, 2-week run-in and 6-week treatment period. Subjects were randomised to consume either yoghurts containing microencapsulated L. reuteri NCIMB 30242 or placebo yoghurts. Over the intervention period, subjects consuming yoghurts containing microencapsulated L. reuteri NCIMB 30242 attained significant reductions in LDL-cholesterol (LDL-C) of 8·92 % (P = 0·016), total cholesterol (TC) of 4·81 % (P = 0·031) and non-HDL-cholesterol (HDL-C) of 6·01 % (P = 0·029) over placebo, and a significant absolute change in apoB-100 of − 0·19 mmol/l (P = 0·049). Serum concentrations of TAG and HDL-C were unchanged over the course of the study. Present results show that consumption of microencapsulated BSH-active L. reuteri NCIMB 30242 yoghurt is efficacious and safe for lowering LDL-C, TC, apoB-100 and non-HDL-C in hypercholesterolaemic subjects. The efficacy of microencapsulated BSH-active L. reuteri NCIMB 30242 yoghurts appears to be superior to traditional probiotic therapy and akin to that of other cholesterol-lowering ingredients.read more
Citations
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Cholesterol-Lowering Probiotics as Potential Biotherapeutics for Metabolic Diseases
Manoj Kumar,Ravinder Nagpal,Rajesh Kumar,Rajkumar Hemalatha,Vinod Verma,Ashok Kumar,Chaitali Chakraborty,Birbal Singh,Francesco Marotta,Shalini Jain,Hariom Yadav +10 more
TL;DR: The present paper reviews the mechanisms of action of anti-cholesterolemic potential of probiotic microorganisms and probiotic food products, with the aim of lowering the risks of cardiovascular and coronary heart diseases.
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Interactions between gut bacteria and bile in health and disease.
TL;DR: The contribution of microbial enzymes to the process of bile acid metabolism in the host is examined and the implications for microbe-host signalling in the context of C. difficile infection, inflammatory bowel disease and other disease states are discussed.
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Lactic Acid Bacteria and Bifidobacteria with Potential to Design Natural Biofunctional Health-Promoting Dairy Foods.
Daniel M. Linares,Daniel M. Linares,Carolina Gomez,E. Renes,José M. Fresno,M.E. Tornadijo,R.P. Ross,Catherine Stanton,Catherine Stanton +8 more
TL;DR: This review aims at discussing the potential of health-supporting bacteria as starter or adjunct cultures for the elaboration of dairy foods with a broad spectrum of new functional properties and added value.
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Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial
TL;DR: The present results suggest that the deconjugation of intraluminal bile acids results in reduced absorption of non-cholesterol sterols and indicate that L. reuteri NCIMB 30242 capsules may be useful as an adjunctive therapy for treating hypercholesterolemia.
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Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure After Myocardial Infarction in the Rat
Xiaohong Tracey Gan,Grace Ettinger,Cathy Huang,Jeremy P. Burton,James V. Haist,Venkatesh Rajapurohitam,James E. Sidaway,Glynn Martin,Gregory B. Gloor,Jonathan R. Swann,Gregor Reid,Morris Karmazyn +11 more
TL;DR: The study suggests that probiotics offer promise as a potential therapy for the attenuation of heart failure.
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