Journal ArticleDOI
Classification of pediatric acute lymphoblastic leukemia by gene expression profiling
Mary E. Ross,Xiaodong Zhou,Guangchun Song,Sheila A. Shurtleff,Kevin Girtman,W. Kent Williams,Hsi Che Liu,Rami Mahfouz,Susana C. Raimondi,Noel Lenny,Anami Patel,James R. Downing +11 more
TLDR
Analysis of leukemic blasts from 132 diagnostic samples using higher density oligonucleotide arrays revealed new insights into the altered biology underlying these leukemias, including T-cell lineage ALL and hyperdiploid karyotypes with more than 50 chromosomes.About:
This article is published in Blood.The article was published on 2003-10-15. It has received 592 citations till now. The article focuses on the topics: Cost effectiveness.read more
Citations
More filters
Journal ArticleDOI
Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children
Oskar A. Haas,Arndt Borkhardt +1 more
TL;DR: It is shown that these two sub-forms of hyperdiploidy can in principle be produced by the same chromosomal maldistribution mechanism and are biologically more similar than hitherto appreciated.
Journal ArticleDOI
Misclassification in binary responses and effect on genome-wide association studies
TL;DR: The results of this study suggest that the proposed method is adequate and effective for practical genome-wide association studies for binary response classification and indicates that ignoring misclassification, when it exists in the data, will lead to major deterioration in the performance of the model.
Book ChapterDOI
Introduction and Classification of Leukemias.
TL;DR: This work describes how both longstanding and new information has influenced classifying, for diagnosis, the hematological malignancies.
Journal ArticleDOI
The application of microarray analysis to pediatric diseases.
TL;DR: DNA microarrays are a tool for simultaneously assessing the expression levels of thousands of genes in a single experiment, making them well-suited to understanding the complex gene response patterns and the regulatory pathways involved in human disease.
Journal ArticleDOI
Downregulation of paraoxonase 3 contributes to aggressive human hepatocellular carcinoma progression and associates with poor prognosis.
Yuepeng Jin,Qiang Li,Junjun Qiu,Xiufen Zhao,Chunxiao Zheng,Shi-xu Lv,Yongyu Bai,Yunfeng Shan,Le-chi Ye +8 more
TL;DR: It is demonstrated that PON3 exhibited tumor-suppressive effects toward HCC and it might serve as a novel prognostic marker in HCC.
References
More filters
Book
Data Mining: Practical Machine Learning Tools and Techniques
TL;DR: This highly anticipated third edition of the most acclaimed work on data mining and machine learning will teach you everything you need to know about preparing inputs, interpreting outputs, evaluating results, and the algorithmic methods at the heart of successful data mining.
Journal ArticleDOI
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring.
Todd R. Golub,Todd R. Golub,Donna K. Slonim,Pablo Tamayo,Christine Huard,Michelle Gaasenbeek,Jill P. Mesirov,Hilary A. Coller,Mignon L. Loh,James R. Downing,Michael A. Caligiuri,Clara D. Bloomfield,Eric S. Lander +12 more
TL;DR: A generic approach to cancer classification based on gene expression monitoring by DNA microarrays is described and applied to human acute leukemias as a test case and suggests a general strategy for discovering and predicting cancer classes for other types of cancer, independent of previous biological knowledge.
Journal ArticleDOI
Nearest neighbor pattern classification
Thomas M. Cover,Peter E. Hart +1 more
TL;DR: The nearest neighbor decision rule assigns to an unclassified sample point the classification of the nearest of a set of previously classified points, so it may be said that half the classification information in an infinite sample set is contained in the nearest neighbor.
Journal ArticleDOI
Data mining: practical machine learning tools and techniques with Java implementations
Ian H. Witten,Eibe Frank +1 more
TL;DR: This presentation discusses the design and implementation of machine learning algorithms in Java, as well as some of the techniques used to develop and implement these algorithms.
Journal ArticleDOI
A Gene-Expression Signature as a Predictor of Survival in Breast Cancer
Marc J. van de Vijver,Yudong D. He,Laura J. van't Veer,Hongyue Dai,Augustinus A. M. Hart,D.W. Voskuil,George J. Schreiber,Johannes L. Peterse,Christopher J. Roberts,Matthew J. Marton,Mark Parrish,Douwe Atsma,Anke T. Witteveen,Annuska M. Glas,Leonie J. M. J. Delahaye,Tony van de Velde,Harry Bartelink,Sjoerd Rodenhuis,Emiel J. Th. Rutgers,Stephen H. Friend,René Bernards +20 more
TL;DR: The gene-expression profile studied is a more powerful predictor of the outcome of disease in young patients with breast cancer than standard systems based on clinical and histologic criteria.
Related Papers (5)
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling.
Eng Juh Yeoh,Mary E. Ross,Sheila A. Shurtleff,W. Kent Williams,Divyen H. Patel,Rami Mahfouz,Frederick G. Behm,Susana C. Raimondi,Mary V. Relling,Anami Patel,Cheng Cheng,Dario Campana,Dawn Wilkins,Xiaodong Zhou,Jinyan Li,Huiqing Liu,Ching-Hon Pui,William E. Evans,Clayton W. Naeve,Limsoon Wong,James R. Downing +20 more