Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
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TLDR
During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.Citations
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SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.
Víctor J. Costela-Ruiz,Rebeca Illescas-Montes,Jose M. Puerta-Puerta,Concepción Ruiz,Lucía Melguizo-Rodríguez +4 more
TL;DR: This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit to support the design of more effective approaches to the management of CO VID-19.
Journal ArticleDOI
Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study.
Andrew Clark,Mark Jit,Charlotte Warren-Gash,Bruce Guthrie,Harry H.X. Wang,Stewart W Mercer,Colin Sanderson,Martin McKee,Christopher Troeger,Kanyin L Ong,Francesco Checchi,Pablo Perel,Sarah Joseph,Hamish Gibbs,Amitava Banerjee,Rosalind M Eggo,Emily Nightingale,Kathleen M. O’Reilly,Thibaut Jombart,W. John Edmunds,Alicia Rosello,Fiona Yueqian Sun,Katherine E. Atkins,Nikos I Bosse,Samuel Clifford,Timothy W Russell,Arminder K Deol,Yang Liu,Simon R Procter,Quentin J Leclerc,Graham F. Medley,Gwen Knight,James D Munday,Adam J. Kucharski,Carl A. B. Pearson,Petra Klepac,Kiesha Prem,Rein M G J Houben,Akira Endo,Stefan Flasche,Nicholas G Davies,Charlie Diamond,Kevin van Zandvoort,Sebastian Funk,Megan Auzenbergs,Eleanor M Rees,Damien C. Tully,Jon C Emery,Billy J Quilty,Sam Abbott,Ch. Julián Villabona-Arenas,Stéphane Hué,Joel Hellewell,Amy Gimma,Christopher I Jarvis +54 more
TL;DR: These estimates provide a starting point for considering the number of individuals that might need to be shielded or vaccinated as the global pandemic unfolds, and focus on underlying conditions rather than other risk factors such as ethnicity, socioeconomic deprivation, and obesity.
Journal ArticleDOI
Age-specific mortality and immunity patterns of SARS-CoV-2.
Megan O'Driscoll,Megan O'Driscoll,Gabriel Ribeiro Dos Santos,Gabriel Ribeiro Dos Santos,Lin Wang,Lin Wang,Derek A. T. Cummings,Andrew S. Azman,Andrew S. Azman,Juliette Paireau,Arnaud Fontanet,Arnaud Fontanet,Simon Cauchemez,Henrik Salje,Henrik Salje +14 more
TL;DR: The relative risk of COVID-19-associated death for younger individuals (under 65) is consistent across countries and can be used to robustly compare the underlying number of infections in each country, and the age distribution of deaths in younger age groups is very consistent across different settings.
Journal ArticleDOI
The procoagulant pattern of patients with COVID-19 acute respiratory distress syndrome.
Marco Ranucci,Andrea Ballotta,Umberto Di Dedda,Ekaterina Bayshnikova,Marco Dei Poli,Marco Resta,Mara Falco,Giovanni Albano,Lorenzo Menicanti +8 more
TL;DR: Few observations exist with respect to the pro‐coagulant profile of patients with COVID‐19 acute respiratory distress syndrome and reports of thromboembolic complications are scarce but suggestive for a clinical relevance of the problem.
Journal ArticleDOI
Myocardial localization of coronavirus in COVID-19 cardiogenic shock.
Guido Tavazzi,Carlo Pellegrini,M. Maurelli,Mirko Belliato,Fabio Sciutti,Andrea Bottazzi,Paola Alessandra Sepe,Tullia Resasco,Rita Camporotondo,Raffaele Bruno,Fausto Baldanti,Stefania Paolucci,S Pelenghi,Giorgio Antonio Iotti,Francesco Mojoli,Eloisa Arbustini +15 more
TL;DR: This is the first case of acute cardiac injury directly linked to myocardial localization of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in a 69‐year‐old patient with flu‐like symptoms rapidly degenerating into respiratory distress, hypotension, and cardiogenic shock.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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