Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
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TLDR
During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.Citations
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COVID-19 with Different Severities: A Multicenter Study of Clinical Features.
Yun Feng,Yun Ling,Tao Bai,Yusang Xie,Jie Huang,Jian Li,Weining Xiong,Dexiang Yang,Rong Chen,Fang-Ying Lu,Yunfei Lu,Xuhui Liu,Yuqing Chen,Xin Li,Yong Li,Hanssa Dwarka Summah,Huihuang Lin,Jiayang Yan,Min Zhou,Hongzhou Lu,Jieming Qu +20 more
TL;DR: Multiple organ dysfunction and impaired immune function were the typical characteristics of patients with severe or critical illness and there was a significant difference in the use of angiotensin-converting enzyme inhibitors/angiotens in II receptor blockers among patients with different severities of disease.
Journal ArticleDOI
ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19.
Janice M. Leung,Janice M. Leung,Chen X. Yang,Chen X. Yang,Anthony Tam,Anthony Tam,Tawimas Shaipanich,Tawimas Shaipanich,Tillie-Louise Hackett,Tillie-Louise Hackett,Gurpreet K. Singhera,Gurpreet K. Singhera,Delbert R. Dorscheid,Delbert R. Dorscheid,Don D. Sin +14 more
TL;DR: Whether patients with COPD have increased expression of ACE-2 in bronchial epithelial cells in the lower respiratory tract is determined, which may explain the increased risk of severe COVID-19 in these subpopulations and highlight the importance of smoking cessation.
Journal ArticleDOI
COVID-19 in solid organ transplant recipients: Initial report from the US epicenter.
Marcus R. Pereira,Sumit Mohan,David J. Cohen,Syed A. Husain,Geoffrey K. Dube,Lloyd E. Ratner,Selim M. Arcasoy,Meghan Aversa,Luke Benvenuto,Darshana Dadhania,Sandip Kapur,Lorna Dove,Robert S. Brown,Russell Rosenblatt,Benjamin Samstein,Nir Uriel,Maryjane Farr,Michael J. Satlin,Catherine B. Small,Thomas J. Walsh,Rosy Priya Kodiyanplakkal,Benjamin A. Miko,Justin G. Aaron,Demetra Tsapepas,Jean C. Emond,Elizabeth C. Verna +25 more
TL;DR: In this initial cohort, transplant recipients with COVID‐19 appear to have more severe outcomes, although testing limitations likely led to undercounting of mild/asymptomatic cases.
Journal ArticleDOI
Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - A systematic review, meta-analysis, and meta-regression.
TL;DR: DM was associated with mortality, severe COVID-19, ARDS, and disease progression in patients with CO VID-19 and the association was weaker in studies with median age ≥55 years-old compared to <55 years old, and in prevalence of hypertension ≥25% compared to<25%.
Journal ArticleDOI
Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial.
Olivier Hermine,Olivier Hermine,Xavier Mariette,Pierre-Louis Tharaux,Matthieu Resche-Rigon,Raphaël Porcher,Philippe Ravaud +6 more
TL;DR: In this randomized clinical trial of patients with COVID-19 and pneumonia requiring oxygen support but not admitted to the intensive care unit, TCZ did not reduce WHO-CPS scores lower than 5 at day 4 but might have reduced the risk of NIV, MV, or death by day 14, and no difference on day 28 mortality was found.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
Journal ArticleDOI
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Na Zhu,Dingyu Zhang,Wenling Wang,Xingwang Li,Bo Yang,Jingdong Song,Xiang Zhao,Baoying Huang,Weifeng Shi,Roujian Lu,Peihua Niu,Faxian Zhan,Xuejun Ma,Dayan Wang,Wenbo Xu,Wenbo Xu,Guizhen Wu,George F. Gao,Wenjie Tan +18 more
TL;DR: Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily, which is the seventh member of the family of coronaviruses that infect humans.
Journal ArticleDOI
Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.
Dawei Wang,Bo Hu,Chang Hu,Fangfang Zhu,Xing Liu,Jing Zhang,Binbin Wang,Hui Xiang,Zhenshun Cheng,Yong Xiong,Yan Zhao,Yirong Li,Xinghuan Wang,Zhiyong Peng +13 more
TL;DR: The epidemiological and clinical characteristics of novel coronavirus (2019-nCoV)-infected pneumonia in Wuhan, China, and hospital-associated transmission as the presumed mechanism of infection for affected health professionals and hospitalized patients are described.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia.
Qun Li,Xuhua Guan,Peng Wu,Xiaoye Wang,Lei Zhou,Yeqing Tong,Ruiqi Ren,Kathy Leung,Eric H. Y. Lau,Jessica Y. Wong,Xuesen Xing,Nijuan Xiang,Yang Wu,Chao Li,Chen Qi,Dan Li,Tian Liu,Jing Zhao,Man Liu,Wenxiao Tu,Chuding Chen,Lianmei Jin,Rui Yang,Qi Wang,Suhua Zhou,Rui Wang,Hui Liu,Yingbo Luo,Yuan Liu,Ge Shao,Huan Li,Zhongfa Tao,Yang Yang,Yang Yang,Zhiqiang Deng,Boxi Liu,Zhitao Ma,Yanping Zhang,Guoqing Shi,Tommy Tsan-Yuk Lam,Joseph T. Wu,George F. Gao,George F. Gao,Benjamin J. Cowling,Bo Yang,Gabriel M. Leung,Zijian Feng +46 more
TL;DR: There is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019 and considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere.
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
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