Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection
Christian Drosten,M Seilmaier,Victor M. Corman,W. J. Hartmann,Gregor Scheible,Stefan Sack,Wolfgang Guggemos,René Kallies,Doreen Muth,Sandra Junglen,Marcel A. Müller,Walter Haas,Hana Guberina,Tim Röhnisch,Monika Schmid-Wendtner,Souhaib Aldabbagh,Ulf Dittmer,Hermann Gold,Petra Graf,Frank Bonin,Andrew Rambaut,Andrew Rambaut,Clemens M. Wendtner +22 more
Reads0
Chats0
TLDR
The first complete viral load profile in a case of MERS-CoV infection is provided, which might have shedding patterns that are different from those of severe acute respiratory syndrome and so might need alternative diagnostic approaches.Abstract:
Summary Background The Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging virus involved in cases and case clusters of severe acute respiratory infection in the Arabian Peninsula, T unisia, Morocco, France, Italy, Germany, and the UK. We provide a full description of a fatal case of MERS-CoV infection and associated phylogenetic analyses. Methods We report data for a patient who was admitted to the Klinikum Schwabing (Munich, Germany) for severe acute respiratory infection. We did diagnostic RT -PCR and indirect immunofl uorescence. From time of diagnosis, respiratory, faecal, and urine samples were obtained for virus quantifi cation. We constructed a maximum likelihood tree of the fi ve available complete MERS-CoV genomes.read more
Citations
More filters
Assessing the pandemic potential of MERS-CoV
TL;DR: Learning from the South African experience, an important new weapon in the war on smokingattributed disease is that the smoking status about 5 years before death should be noted when registering causes of death, ideally in every population where underlying cause of death are assigned.
Journal ArticleDOI
Middle East respiratory syndrome (MERS 2012): roles of clinical pathology laboratory for screening and diagnosis.
Sora Yasri,Viroj Wiwanitkit +1 more
Book ChapterDOI
Middle East Respiratory Syndrome Coronavirus Outbreaks
TL;DR: The Middle East respiratory syndrome coronavirus (MERS-CoV) is a single-stranded RNA-enveloped virus that belongs to the Coronaviridae family as mentioned in this paper .
Journal ArticleDOI
Assessment of some Physiological Biomarkers in COVID-19 Patients in Thi-Qar, Iraq.
TL;DR: In this paper , the authors evaluated the association of lactate dehydrogenase (LDH), D-Dimer, vitamin D, and ferritin statuses with the prognosis of COVID-19; moreover, they attempted to investigate its prevalence according to age, employment status, body mass index (BMI), and place of residency.
Evaluating the pandemic potential of MERS-CoV
Chris T. Bauch,Tamer Oraby +1 more
TL;DR: The emergence in 2012 of a new disease-causing coronavirus has caused significant concern and raises the question: does MERS-CoV have the potential to cause a pandemic?
References
More filters
Journal ArticleDOI
A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood.
Stéphane Guindon,Olivier Gascuel +1 more
TL;DR: This work has used extensive and realistic computer simulations to show that the topological accuracy of this new method is at least as high as that of the existing maximum-likelihood programs and much higher than the performance of distance-based and parsimony approaches.
Journal ArticleDOI
Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia
Ali Moh Zaki,Sander van Boheemen,Theo M. Bestebroer,Albert D. M. E. Osterhaus,Ron A. M. Fouchier +4 more
TL;DR: The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Journal ArticleDOI
Identification of a novel coronavirus in patients with severe acute respiratory syndrome.
Christian Drosten,Stephan Günther,Wolfgang Preiser,Sylvie van der Werf,H. R. Brodt,Stephan Becker,Holger F. Rabenau,Marcus Panning,Larissa Kolesnikova,Ron A. M. Fouchier,Annemarie Berger,Ana-Maria Burguière,Jindrich Cinatl,Markus Eickmann,Nicolas Escriou,Klaus Grywna,Stefanie Kramme,Jean-Claude Manuguerra,Stefanie Müller,Volker Rickerts,Martin Stürmer,Simon Vieth,Hans-Dieter Klenk,Albert D. M. E. Osterhaus,Herbert Schmitz,Hans Wilhelm Doerr +25 more
TL;DR: The novel coronavirus might have a role in causing SARS and was detected in a variety of clinical specimens from patients with SARS but not in controls.
Journal ArticleDOI
The severe acute respiratory syndrome.
TL;DR: The concerted and coordinated response that contained SARS is a triumph for global public health and provides a new paradigm for the detection and control of future emerging infectious disease threats.
Journal ArticleDOI
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
V. Stalin Raj,Huihui Mou,Saskia L. Smits,Dick H. W. Dekkers,Marcel A. Müller,Ronald Dijkman,Doreen Muth,Jeroen Demmers,Ali Moh Zaki,Ron A. M. Fouchier,Volker Thiel,Volker Thiel,Christian Drosten,Peter J. M. Rottier,Albert D. M. E. Osterhaus,Berend Jan Bosch,Bart L. Haagmans +16 more
TL;DR: Dipeptidyl peptidase 4 (DPP4; also known as CD26) is identified as a functional receptor for hCoV-EMC and will contribute critically to the understanding of the pathogenesis and epidemiology of this emerging human coronavirus, and may facilitate the development of intervention strategies.
Related Papers (5)
Hospital Outbreak of Middle East Respiratory Syndrome Coronavirus
Abdullah M. Assiri,Allison McGeer,Trish M. Perl,Connie S. Price,Abdullah A. Al Rabeeah,Derek A. T. Cummings,Zaki N. Alabdullatif,Maher Assad,Abdulmohsen Almulhim,Hatem Q. Makhdoom,Hossam Madani,Rafat F. Alhakeem,Jaffar A. Al-Tawfiq,Matthew Cotten,Simon J. Watson,Paul Kellam,Paul Kellam,Alimuddin Zumla,Alimuddin Zumla,Ziad A. Memish +19 more
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
Chantal B.E.M. Reusken,Bart L. Haagmans,Marcel A. Müller,Carlos Gutierrez,Gert Jan Godeke,Benjamin Meyer,Doreen Muth,V. Stalin Raj,Laura Smits De Vries,Victor M. Corman,Jan Felix Drexler,Saskia L. Smits,Yasmin El Tahir,Rita de Sousa,Janko van Beek,Norbert Nowotny,Norbert Nowotny,Kees van Maanen,Ezequiel Hidalgo-Hermoso,Berend Jan Bosch,Peter J. M. Rottier,Albert D. M. E. Osterhaus,Christian Gortázar-Schmidt,Christian Drosten,Marion Koopmans +24 more