Clinical Relevance of RNA Editing to Early Detection of Cancer in Human.
Mujib Ullah,Asma Akbar +1 more
TLDR
Studying RNA editing and its application to change genetic information after transcription, RNA-editing technology could be an important innovation in cancer and has the potential for more effective precision treatment.Abstract:
DNA encodes RNA and is responsible for protein production in cells. RNA editing is the process by which genetic information is altered in the RNA molecule. RNA editing in cancer initiation, progression and development has been well documented and play an important role in tumorigenesis. Studying RNA editing and its application to change genetic information after transcription, RNA-editing technology could be an important innovation in cancer and has the potential for more effective precision treatment. Bioengineering integration approach and artificial intelligence could revolutionize the entire field of RNA editing for early detection of cancer.read more
Citations
More filters
Journal ArticleDOI
Microbubbles versus Extracellular Vesicles as Therapeutic Cargo for Targeting Drug Delivery.
TL;DR: Extracellular vesicles (EVs) and microbubbles are nanoparticles in drug-delivery systems that are both considered important for clinical translation as discussed by the authors, however, there are no standards to evaluate or to compare the benefits of EVs (natural carrier) versus micro-bubbles (synthetic carrier) as drug carriers.
Journal ArticleDOI
Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications
TL;DR: The sources of extracellular vesicles, including plant, salivary and urinary sources which are easily available but less sought after compared with blood and tissue are discussed.
Journal ArticleDOI
Diagnostic and Therapeutic Potential of Extracellular Vesicles.
Sai Priyanka Kodam,Mujib Ullah +1 more
TL;DR: Extracellular vesicles (EVs) are naturally phospholipid enclosed nanoveicles released by many cells in the body as discussed by the authors, which are stable in circulation, have low immunogenicity, and act as carriers for functionally active biological molecules.
Journal ArticleDOI
Different Sourced Extracellular Vesicles and Their Potential Applications in Clinical Treatments
Leila Bahmani,Mujib Ullah +1 more
TL;DR: This review describes in detail different EVs derived from distinct cell sources, compare their advantages and disadvantages, and recapitulate their therapeutic effects on various human disorders to highlight the progress made in harnessing EVs for clinical applications.
Journal ArticleDOI
Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response
TL;DR: The advent of advanced exosomes purification methods has made it possible to tap on the unexplored potential of these tiny particles in clinically-precise diagnosis and treatment of a myriad of diseases, and the recent COVID19 pandemic has opened up new opportunities for exosome technology to benefit humankind.
References
More filters
Journal ArticleDOI
RADAR: a rigorously annotated database of A-to-I RNA editing
Gokul Ramaswami,Jin Billy Li +1 more
TL;DR: RADAR includes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), mice and flies (Mus musculus) and flies, together with extensive manually curated annotations for each editing site.
Journal ArticleDOI
DARNED: a DAtabase of RNa EDiting in humans
Anmol M. Kiran,Pavel V. Baranov +1 more
TL;DR: A new database DARNED (DAtabase of RNa EDiting) is described that provides centralized access to available published data related to RNA editing and is designed for researchers seeking information onRNA editing and for the developers of novel algorithms for its prediction.
Journal ArticleDOI
The Role of RNA Editing in Cancer Development and Metabolic Disorders.
TL;DR: The impact of RNA editing on the development of cancer and metabolic disorders will be examined, and distinctive functions of each RNA editase that regulate either A- to-I or C-to-U editing will be highlighted in addition to pointing out important regulatory mechanisms governing these processes.
Journal ArticleDOI
Cis- and trans-regulations of pre-mRNA splicing by RNA editing enzymes influence cancer development.
Sze Jing Tang,Haoqing Shen,Omer An,HuiQi Hong,Jia Li,Yangyang Song,Jian Han,Daryl Jin Tai Tay,Vanessa Hui En Ng,Fernando Bellido Molias,Ka Wai Leong,Priyankaa Pitcheshwar,Henry Yang,Leilei Chen +13 more
TL;DR: Crosstalk between RNA editing and splicing is reported by identifying ADAR1/2-dependent splicing events in esophageal squamous carcinoma cells and finding these ADARs-regulated splicing changes per se influence tumorigenesis, not merely byproducts ofADARs editing and binding.
Journal ArticleDOI
Critical review on engineering deaminases for site-directed RNA editing.
Paul Vogel,Thorsten Stafforst +1 more
TL;DR: It is concluded that the CRISPR/Cas system seems not generally superior to other RNA targeting strategies in solving the most pressing problem in the RNA editing field, which is to obtain high efficiency in combination with high specificity.