Journal ArticleDOI
Microbubbles versus Extracellular Vesicles as Therapeutic Cargo for Targeting Drug Delivery.
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TLDR
Extracellular vesicles (EVs) and microbubbles are nanoparticles in drug-delivery systems that are both considered important for clinical translation as discussed by the authors, however, there are no standards to evaluate or to compare the benefits of EVs (natural carrier) versus micro-bubbles (synthetic carrier) as drug carriers.Abstract:
Extracellular vesicles (EVs) and microbubbles are nanoparticles in drug-delivery systems that are both considered important for clinical translation. Current research has found that both microbubbles and EVs have the potential to be utilized as drug-delivery agents for therapeutic targets in various diseases. In combination with EVs, microbubbles are capable of delivering chemotherapeutic drugs to tumor sites and neighboring sites of damaged tissues. However, there are no standards to evaluate or to compare the benefits of EVs (natural carrier) versus microbubbles (synthetic carrier) as drug carriers. Both drug carriers are being investigated for release patterns and for pharmacokinetics; however, few researchers have focused on their targeted delivery or efficacy. In this Perspective, we compare EVs and microbubbles for a better understanding of their utility in terms of delivering drugs to their site of action and future clinical translation.read more
Citations
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Journal ArticleDOI
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis
Chengqi Yan,Cheng Wang,Meng-Dan Yuan,Yu Kang,Zihan Wu,Wenqing Li,Guoyu Zhang,Hans-Günther Machens,Yuval Rinkevich,Zhenbing Chen,Xiaofan Yang,Xiang Xu +11 more
TL;DR: The feasibility of milk exosomes as a scalable, biocompatible, and cost-effective delivery system to enhance the bioavailability and efficacy of miRNAs is shown.
Journal ArticleDOI
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities.
Bethany Claridge,Bethany Claridge,Jonathan Lozano,Jonathan Lozano,Qi Hui Poh,Qi Hui Poh,David W. Greening +6 more
TL;DR: Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their endogenous characteristics, however, further bioengineering refinement is required to address clinical and commercial limitations as discussed by the authors.
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Engineering stem cells to produce exosomes with enhanced bone regeneration effects: an alternative strategy for gene therapy
Feiyang Li,Jun Wu,Daiye Li,Liuzhi Hao,Yanqun Li,Dan Yi,Kelvin W.K. Yeung,Di Chen,William W. Lu,Haobo Pan,Tak Man Wong,Xiaoli Zhao +11 more
TL;DR: In this article , a stem cell-mediated gene therapy strategy is developed in which mediator mesenchymal stem cells are genetically engineered by bone morphogenetic protein-2 gene to produce exosomes (MSC-BMP2-Exo) with enhanced bone regeneration potency.
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Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications
TL;DR: The sources of extracellular vesicles, including plant, salivary and urinary sources which are easily available but less sought after compared with blood and tissue are discussed.
Journal ArticleDOI
Tumor-Derived Extracellular Vesicles: Their Role in Immune Cells and Immunotherapy.
TL;DR: Wang et al. as mentioned in this paper reviewed the effects of tumor-derived extracellular vesicles on immune cells in recent years and also summarized their research progress in the tumor immunotherapy and diagnosis.
References
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Journal ArticleDOI
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go.
Mercedes Tkach,Clotilde Théry +1 more
TL;DR: This Review focuses on the context of tumor cells and their microenvironment, but similar results and challenges apply to all patho/physiological systems in which EV-mediated communication is proposed to take place.
Journal ArticleDOI
Classification, Functions, and Clinical Relevance of Extracellular Vesicles
TL;DR: Evidence is accumulating that vesicles are cargo containers used by eukaryotic cells to exchange biomolecules as transmembrane receptors and genetic information, and they have a myriad of potential clinical applications, ranging from biomarkers to anticancer therapy.
Journal ArticleDOI
Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain
Xiaoying Zhuang,Xiaoyu Xiang,William E. Grizzle,Dongmei Sun,Shuangqin Zhang,Robert C. Axtell,Songwen Ju,Jiangyao Mu,Lifeng Zhang,Lawrence Steinman,Donald R. Miller,Huang-Ge Zhang,Huang-Ge Zhang +12 more
TL;DR: Exosomes used to encapsulate curcumin or a signal transducer and activator of transcription 3 (Stat3) inhibitor were delivered noninvasively to microglia cells via an intranasal route and demonstrated that this strategy may provide a noninvasive and novel therapeutic approach for treating brain inflammatory-related diseases.
Journal ArticleDOI
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies.
TL;DR: The biologic processes that give rise to various types of EVs, including exosomes, microvesicles, retrovirus like particles, and apoptotic bodies are reviewed and clinical pertinence of these EVs to neuro-oncology will also be discussed.
Journal ArticleDOI
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper
Thomas Lener,Mario Gimona,Ludwig Aigner,Verena Börger,Edit I. Buzás,Giovanni Camussi,Nathalie Chaput,Devasis Chatterjee,Felipe A. Court,Hernando A. del Portillo,Lorraine O'Driscoll,Stefano Fais,Juan M. Falcón-Pérez,Ursula Felderhoff-Mueser,Lorenzo Fraile,Yong Song Gho,André Görgens,Ramesh C. Gupta,An Hendrix,Dirk M. Hermann,Andrew F. Hill,Fred H. Hochberg,Peter A. Horn,Dominique P.V. de Kleijn,Lambros Kordelas,Boris W. Kramer,Eva-Maria Krämer-Albers,Sandra Laner-Plamberger,Saara Laitinen,Tommaso Leonardi,Magdalena J. Lorenowicz,Sai Kiang Lim,Jan Lötvall,Casey A. Maguire,Antonio Marcilla,Irina Nazarenko,Takahiro Ochiya,Tushar Patel,Shona Pedersen,Gabriella Pocsfalvi,Stefano Pluchino,Peter J. Quesenberry,Ilona G. Reischl,Francisco J. Rivera,Ralf Sanzenbacher,Katharina Schallmoser,Ineke Slaper-Cortenbach,Dirk Strunk,Torsten Tonn,Pieter Vader,Pieter Vader,Bas W.M. van Balkom,Marca H. M. Wauben,Samir El Andaloussi,Samir El Andaloussi,Clotilde Théry,Eva Rohde,Bernd Giebel +57 more
TL;DR: In this paper, the authors summarize recent developments and the current knowledge of extracellular vesicles (EVs) and discuss safety and regulatory requirements that must be considered for pharmaceutical manufacturing and clinical application.
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